PMID- 21395662
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20221207
IS  - 1348-0421 (Electronic)
IS  - 0385-5600 (Linking)
VI  - 55
IP  - 6
DP  - 2011 Jun
TI  - Relationship between single nucleotide polymorphism of interleukin-18 and 
      susceptibility to pulmonary tuberculosis in the Chinese Han population.
PG  - 388-93
LID - 10.1111/j.1348-0421.2011.00332.x [doi]
AB  - Interleukin-18 (IL-18) is a multi-functional cytokine capable of inducing either 
      Th1 or Th2 polarization depending on the immunologic milieu. IL-18 may influence 
      the host response to Mycobacterium tuberculosis (M.tb) infection. To investigate 
      the relationship between single nucleotide polymorphisms of the IL-18 and 
      susceptibility to pulmonary tuberculosis in the Chinese Han population, the IL-18 
      gene was sequenced to detect polymorphisms and to examine the genotype 
      frequencies in 300 patients and 702 healthy controls. DNA sequencing revealed 
      three IL-18 variants: rs1946518, rs5744247, and rs549908. It also revealed that 
      allele A of rs1946518 confers a 1.47-fold increased risk of developing 
      tuberculosis (TB) (P = 0.0001, OR [95%CI] = 1.47 [1.21-1.78]), and that the C 
      allele of rs5744247 confers a 0.77-fold decreased risk of disease (P = 0.01, R 
      [95%CI] = 0.77 [0.632-0.937]). The genotypes rs1946518, rs5744247 and rs549908 
      were found to be significantly associated with TB. Estimation of the frequencies 
      of haplotypes revealed a potential risk haplotype AGA (P = 0.01, OR [95%CI] = 
      1.41 [1.15-1.72]) and a protective haplotype CCA (P = 0.01, OR [95%CI] = 0.70 
      [0.57-0.85]) for TB. The present findings suggest that polymorphisms in the IL-18 
      gene may affect susceptibility to TB and increase the risk of developing the 
      disease in the Chinese Han population.
CI  - (c) 2011 The Societies and Blackwell Publishing Asia Pty Ltd.
FAU - Han, Min
AU  - Han M
AD  - Shanghai Key Laboratory of Mycobacterium Tuberculosis, Shanghai Pulmonary 
      Hospital Affiliated to Tongji University School of Medicine, 507 Zhengmin Rd, 
      Shanghai, China.
FAU - Yue, Jun
AU  - Yue J
FAU - Lian, Yuan-Yuan
AU  - Lian YY
FAU - Zhao, Yan-Lin
AU  - Zhao YL
FAU - Wang, Hong-Xiu
AU  - Wang HX
FAU - Liu, Li-Rong
AU  - Liu LR
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Microbiol Immunol
JT  - Microbiology and immunology
JID - 7703966
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-18/*genetics/*immunology
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium tuberculosis/immunology/pathogenicity
MH  - *Polymorphism, Single Nucleotide
MH  - Tuberculosis, Pulmonary/*genetics/*immunology
MH  - Young Adult
EDAT- 2011/03/15 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - 10.1111/j.1348-0421.2011.00332.x [doi]
PST - ppublish
SO  - Microbiol Immunol. 2011 Jun;55(6):388-93. doi: 10.1111/j.1348-0421.2011.00332.x.