PMID- 21396928
OWN - NLM
STAT- MEDLINE
DCOM- 20120808
LR  - 20110425
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 412
IP  - 11-12
DP  - 2011 May 12
TI  - Free immunoglobulin light chain: its biology and implications in diseases.
PG  - 843-9
LID - 10.1016/j.cca.2011.03.007 [doi]
AB  - Immunoglobulin light chain (IgLC) is a component of antibodies, but its free form 
      is observed in the circulation, which originates from 10 to 40% excess synthesis 
      over heavy chain in B cells. Complete antibodies function as a defined tetramer 
      structure unit, H2L2; thus, separation of heavy and light chains results in 
      considerable or complete loss of antigen-binding ability. Free IgLC has been 
      considered as an inconsequential spillover during antibody assembly because, 
      unlike heavy chain, neither effector functions such as complement activation nor 
      specific-receptor binding has been identified in IgLCs. Free IgLC in sera and 
      cerebrospinal fluids increases in inflammatory diseases such as autoimmune 
      diseases and infections, presumably as a result of B-cell activation. This may be 
      just a concomitant event during elevated disease activity, but recent findings 
      suggest that free IgLC is involved in a wide range of immunological phenomena as 
      a signaling effector or an anti-inflammatory molecule. These effects are likely 
      to be intrinsic to IgLC. In this review, we attempt to give a comprehensive view 
      about the biological roles of free IgLC together with the gene expression, 
      secretion, antigen-binding ability, and its metabolic characteristics.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Nakano, Takanari
AU  - Nakano T
AD  - Department of Biochemistry, Faculty of Medicine, Saitama Medical University, 
      Saitama, Japan. nk.takanari@gmail.com
FAU - Matsui, Masanori
AU  - Matsui M
FAU - Inoue, Ikuo
AU  - Inoue I
FAU - Awata, Takuya
AU  - Awata T
FAU - Katayama, Shigehiro
AU  - Katayama S
FAU - Murakoshi, Takayuki
AU  - Murakoshi T
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110315
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Antigens)
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Animals
MH  - Antigens/immunology
MH  - Disease
MH  - Gene Expression Regulation
MH  - Humans
MH  - Immunoglobulin Light Chains/biosynthesis/immunology/*metabolism
EDAT- 2011/03/15 06:00
MHDA- 2012/08/09 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/02/08 00:00 [received]
PHST- 2011/02/28 00:00 [revised]
PHST- 2011/03/03 00:00 [accepted]
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2012/08/09 06:00 [medline]
AID - S0009-8981(11)00136-7 [pii]
AID - 10.1016/j.cca.2011.03.007 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2011 May 12;412(11-12):843-9. doi: 10.1016/j.cca.2011.03.007. 
      Epub 2011 Mar 15.