PMID- 21397530
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20151119
IS  - 1532-2165 (Electronic)
IS  - 1078-5884 (Linking)
VI  - 42
IP  - 2
DP  - 2011 Aug
TI  - Walking performance and health-related quality of life after surgical or 
      endovascular invasive versus non-invasive treatment for intermittent 
      claudication--a prospective randomised trial.
PG  - 220-7
LID - 10.1016/j.ejvs.2011.02.019 [doi]
AB  - OBJECTIVES: Despite limited scientific evidence for the effectiveness of invasive 
      treatment for intermittent claudication (IC), revascularisation procedures for IC 
      are increasingly often performed in Sweden. This randomised controlled trial 
      compares the outcome after 2 years of primary invasive (INV) versus primary 
      non-invasive (NON) treatment strategies in unselected IC patients. 
      MATERIALS/METHODS: Based on arterial duplex and clinical examination, IC patients 
      were randomised to INV (endovascular and/or surgical, n = 100) or NON (n = 101). 
      NON patients could request invasive treatment if they deteriorated during 
      follow-up. Primary outcome was maximal walking performance (MWP) on graded 
      treadmill test at 2 years and secondary outcomes included health-related quality 
      of life (HRQL), assessed with Short Form (36) Health Survey (SF-36). RESULTS: MWP 
      was not significantly (p = 0.104) improved in the INV versus the NON group. Two 
      SF-36 physical subscales, Bodily Pain (p < 0.01) and Role Physical (p < 0.05) 
      improved significantly more in the INV versus the NON group. There were 7% 
      crossovers against the study protocol in the INV group. CONCLUSIONS: Although 
      invasive treatment did not show any significant advantage regarding MWP, the HRQL 
      improvements associated with invasive treatment tentatively suggest secondary 
      benefits of this regimen. On the other hand, a primary non-invasive treatment 
      strategy seems to be accepted by most IC patients.
CI  - Copyright (c) 2011 European Society for Vascular Surgery. Published by Elsevier 
      Ltd. All rights reserved.
FAU - Nordanstig, J
AU  - Nordanstig J
AD  - Department of Vascular Surgery, Sahlgrenska University Hospital, Sweden. 
      joakim.nordanstig@vgregion.se
FAU - Gelin, J
AU  - Gelin J
FAU - Hensater, M
AU  - Hensater M
FAU - Taft, C
AU  - Taft C
FAU - Osterberg, K
AU  - Osterberg K
FAU - Jivegard, L
AU  - Jivegard L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110311
PL  - England
TA  - Eur J Vasc Endovasc Surg
JT  - European journal of vascular and endovascular surgery : the official journal of 
      the European Society for Vascular Surgery
JID - 9512728
RN  - 0 (Cardiovascular Agents)
SB  - IM
CIN - Eur J Vasc Endovasc Surg. 2011 Aug;42(2):228-9. PMID: 21531592
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiography, Digital Subtraction
MH  - Ankle Brachial Index
MH  - Cardiovascular Agents/*therapeutic use
MH  - *Endovascular Procedures
MH  - Exercise Test
MH  - *Exercise Therapy
MH  - Female
MH  - Humans
MH  - Intermittent Claudication/diagnosis/physiopathology/psychology/*surgery
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Patient Selection
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Recovery of Function
MH  - Risk Reduction Behavior
MH  - Surveys and Questionnaires
MH  - Sweden
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ultrasonography, Doppler, Duplex
MH  - *Vascular Surgical Procedures
MH  - *Walking
EDAT- 2011/03/15 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/03/15 06:00
PHST- 2010/09/14 00:00 [received]
PHST- 2011/02/13 00:00 [accepted]
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S1078-5884(11)00096-7 [pii]
AID - 10.1016/j.ejvs.2011.02.019 [doi]
PST - ppublish
SO  - Eur J Vasc Endovasc Surg. 2011 Aug;42(2):220-7. doi: 10.1016/j.ejvs.2011.02.019. 
      Epub 2011 Mar 11.