PMID- 21397543
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20171116
IS  - 1953-8022 (Electronic)
IS  - 1246-7820 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Apr
TI  - [HLA and transfusion: new approaches with Luminex technology].
PG  - 218-23
LID - 10.1016/j.tracli.2011.01.004 [doi]
AB  - The major histocompatibility complex is a multigenic system highly polymorphic 
      coding for human leukocyte antigen (HLA) molecules, which are the strongest 
      antigens for immune response and play a major role in allograft rejection. Class 
      I antigens are expressed on almost all nucleated cells and platelets, whereas HLA 
      class II antigens are mostly on antigen presenting cells. During transfusion, 
      anti-HLA antibodies can induce transfusion incidents like fever, 
      transfusion-related acute lung injury TRALI and refractoriness to the platelets 
      transfusion. Identification of HLA class I antibodies is very important to find 
      HLA compatible platelets concentrates. Since the end of 1960s, the 
      complement-dependent microlymphocytotoxicity assay has been the standard 
      internationally recognized method for cross matching and screening of HLA 
      antibodies. It became necessary to improve the test sensitivity because some 
      clinical relevant antibodies were not detected. Sensitive methods appeared in the 
      1990 s: flow cytometry, enzyme-linked immunosorbent assay and now Luminex. This 
      latter is the most sensitive method with single HLA antigen panel assays to 
      generate the most informative reactivity pattern of antibodies. The high 
      sensitivity and specificity of the Luminex technology performed to screen HLA 
      antibodies allows the best selection of platelets donors. When no compatible 
      concentrates are available for highly immunized recipients, the cross-matching 
      method could be used to select a platelet concentrate.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Giannoli, C
AU  - Giannoli C
AD  - Laboratoire d'histocompatibilite, site de Lyon, EFS Rhone-Alpes, 1-3, rue du 
      Vercors, 69007 Lyon, France. catherine.giannoli@efs.sante.fr
FAU - Nguyen, T-K-T
AU  - Nguyen TK
FAU - Dubois, V
AU  - Dubois V
LA  - fre
PT  - Journal Article
PT  - Review
TT  - HLA et transfusion: nouvelles approches a l'ere du Luminex.
DEP - 20110311
PL  - France
TA  - Transfus Clin Biol
JT  - Transfusion clinique et biologique : journal de la Societe francaise de 
      transfusion sanguine
JID - 9423846
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Isoantibodies)
RN  - 11016-17-4 (Phycoerythrin)
SB  - IM
MH  - Acute Lung Injury/etiology/immunology/prevention & control
MH  - Antibodies, Anti-Idiotypic/immunology
MH  - Blood Platelets/*immunology
MH  - *Blood Transfusion
MH  - Cross Reactions
MH  - Donor Selection/*methods/standards
MH  - Flow Cytometry/*methods
MH  - Fluorescent Dyes
MH  - HLA Antigens/*analysis
MH  - Histocompatibility Testing/instrumentation/*methods/standards
MH  - Humans
MH  - Immunoglobulin G/immunology
MH  - Isoantibodies/*blood
MH  - Microspheres
MH  - Phycoerythrin
MH  - Platelet Transfusion/adverse effects
MH  - Sensitivity and Specificity
MH  - Transfusion Reaction
EDAT- 2011/03/15 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/01/21 00:00 [received]
PHST- 2011/01/27 00:00 [accepted]
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - S1246-7820(11)00005-X [pii]
AID - 10.1016/j.tracli.2011.01.004 [doi]
PST - ppublish
SO  - Transfus Clin Biol. 2011 Apr;18(2):218-23. doi: 10.1016/j.tracli.2011.01.004. 
      Epub 2011 Mar 11.