PMID- 21398410
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20220321
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 95
IP  - 12
DP  - 2011 Dec
TI  - Retinal nerve fibre layer and macular thickness in amblyopia as measured by 
      spectral-domain optical coherence tomography.
PG  - 1696-9
LID - 10.1136/bjo.2010.195081 [doi]
AB  - BACKGROUND/AIMS: To study peripapillary retinal nerve fibre layer (RNFL) and 
      macular thickness in amblyopia using high-definition spectral-domain optical 
      coherence tomography (SD-OCT) and to compare the results with available 
      literature using the time-domain modality. METHODS: This was a prospective 
      institutional study of patients >/= 6 years of age with unilateral amblyopia 
      (strabismic or anisometropic) and non-amblyopic anisometropia. RNFL and macular 
      thicknesses were measured using SD-OCT and compared between fellow eyes. RESULTS: 
      The mean age was 20 (+/- 12) years; 45 patients had amblyopia: 14 strabismic and 31 
      anisometropic. 20 patients had non-amblyopic anisometropia. The mean macular 
      thickness was significantly increased in the amblyopic (273.8 mum) vs fellow eyes 
      (257.9 mum), p=0.001. This difference remained significant in the anisometropic 
      group (p=0.002) but not the strabismic group. The mean RNFL thickness was similar 
      in amblyopic (95.4 mum) and fellow eyes (94.0 mum). Similar results were obtained 
      regardless of the level of visual acuity, age or refractive error. In the control 
      group of non-amblyopic anisometropia, the interocular difference did not reach 
      statistical significance. CONCLUSIONS: Central macular thickness was 
      significantly increased in anisometropic amblyopia using SD-OCT. Anisometropia 
      alone did not produce such a difference, which points to a possible correlation 
      between amblyopia and the development of the retinal layers.
FAU - Al-Haddad, Christiane E
AU  - Al-Haddad CE
AD  - Department of Ophthalmology, American University of Beirut, Beirut, Lebanon. 
      ca12@aub.edu.lb
FAU - Mollayess, Georges M E L
AU  - Mollayess GM
FAU - Cherfan, Carol G
AU  - Cherfan CG
FAU - Jaafar, Dalida F
AU  - Jaafar DF
FAU - Bashshur, Ziad F
AU  - Bashshur ZF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110311
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
SB  - IM
MH  - Adult
MH  - Amblyopia/*diagnostic imaging/*pathology
MH  - Anisometropia/diagnostic imaging/pathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Macula Lutea/diagnostic imaging/*pathology
MH  - Male
MH  - Nerve Fibers/diagnostic imaging/*pathology
MH  - Prospective Studies
MH  - Radiography
MH  - Retinal Neurons/diagnostic imaging/*pathology
MH  - Strabismus/diagnostic imaging/pathology
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity
EDAT- 2011/03/15 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - bjo.2010.195081 [pii]
AID - 10.1136/bjo.2010.195081 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2011 Dec;95(12):1696-9. doi: 10.1136/bjo.2010.195081. Epub 2011 
      Mar 11.