PMID- 21400268
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151030
LR  - 20110314
IS  - 1064-3745 (Print)
IS  - 1064-3745 (Linking)
VI  - 15
DP  - 1993
TI  - Mapping MHC Class II Genes and Disease-Susceptibility : Use of Polymerase Chain 
      Reaction and Dot Hybridization for Human Leukocyte Antigen Allele Typing.
PG  - 95-112
LID - 10.1385/0-89603-244-2:95 [doi]
AB  - The genes of the human leukocyte antigen (HLA) region control a variety of 
      functions involved in the immune response and influence susceptibility to over 40 
      diseases. The region maps to the short arm of chromosome 6 and is divided into 
      three regions, denoted class I, II, and III. The HLA class II gene complex is 
      approx 1000 kb in length and is arranged into three main subregions (HLA-DP, -DQ, 
      and -DR), each of which contains genes of two types, A and B. The A genes encode 
      alpha-polypeptides and B genes encode beta-polypeptides; together these form the 
      functional class II alphabeta dimer. Although some haplotypes contain up to 14 class II 
      loci, not all are expressed, and limitations on functionally permissive 
      heterodimer formation restricts the expressed repertoire to 4 class II 
      molecules/haplotype: DPalphabeta, DQalphabeta, DRalphabeta(1), and DRalphabeta(3,4,5)(the second DR molecule 
      is either DRalphabeta(3), DRalphabeta(4), or DRalphabeta(5), depending on the haplotype). With the 
      exception of the DRA locus, the genes encoding each of these polypeptides are 
      highly polymorphic.
FAU - Bain, S C
AU  - Bain SC
AD  - John Radcliffe Hospital, University of Oxford, Headington, Oxford, UK.
FAU - Todd, J A
AU  - Todd JA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
AID - 10.1385/0-89603-244-2:95 [doi]
PST - ppublish
SO  - Methods Mol Biol. 1993;15:95-112. doi: 10.1385/0-89603-244-2:95.