PMID- 21400519
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20201215
IS  - 1096-9098 (Electronic)
IS  - 0022-4790 (Linking)
VI  - 103
IP  - 5
DP  - 2011 Apr
TI  - Prognostic significance of HLA class I expression in Ewing's sarcoma family of 
      tumors.
PG  - 380-5
LID - 10.1002/jso.21829 [doi]
AB  - BACKGROUND: Ewing's sarcoma family of tumors (ESFT) is one of the most malignant 
      groups of tumors in young people. Human leukocyte antigen (HLA) class I displays 
      endogenously processed peptides to CD8+ T lymphocytes and has a key role for host 
      immune surveillance. In ESFT, the investigation concerning both HLA class I 
      expression and T-cell infiltration has yet to be reported. METHODS: Biopsy 
      specimens from 28 ESFT patients were evaluated by immunohistochemistry with the 
      anti-HLA class I monoclonal antibody (mAb) EMR8-5 and anti-CD8 mAb, respectively. 
      RESULTS: Expression of HLA class I was negative in 10 tumors and down-regulated 
      in 22 tumors. The status of CD8+ T cell infiltration was closely associated with 
      the expression levels of HLA class I. ESFT patients with down-regulated or 
      negative expression of HLA class I showed significantly poorer survival than the 
      rest of the patients. CONCLUSIONS: Our results suggested that CD8+ T 
      cell-mediated immune response restricted by HLA class I might play an important 
      role in immune surveillance of ESFT, and we revealed for the first time that the 
      status of HLA class I expression affects the survival of the patients with ESFT.
CI  - Copyright (c) 2010 Wiley-Liss, Inc.
FAU - Yabe, Hiroki
AU  - Yabe H
AD  - Division of Rheumatology, Jichi Medical University Saitama Medical Center, 
      Saitama, Japan.
FAU - Tsukahara, Tomohide
AU  - Tsukahara T
FAU - Kawaguchi, Satoshi
AU  - Kawaguchi S
FAU - Wada, Takuro
AU  - Wada T
FAU - Torigoe, Toshihiko
AU  - Torigoe T
FAU - Sato, Noriyuki
AU  - Sato N
FAU - Terai, Chihiro
AU  - Terai C
FAU - Aoki, Masaya
AU  - Aoki M
FAU - Hirose, Shigemichi
AU  - Hirose S
FAU - Morioka, Hideo
AU  - Morioka H
FAU - Yabe, Hiroo
AU  - Yabe H
LA  - eng
PT  - Journal Article
DEP - 20101228
PL  - United States
TA  - J Surg Oncol
JT  - Journal of surgical oncology
JID - 0222643
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bone Neoplasms/immunology/*metabolism/pathology
MH  - CD8-Positive T-Lymphocytes/*immunology/pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - Infant
MH  - Lymphocytes, Tumor-Infiltrating/*immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Sarcoma, Ewing/immunology/*metabolism/pathology
MH  - Survival Rate
MH  - Young Adult
EDAT- 2011/03/15 06:00
MHDA- 2011/05/24 06:00
CRDT- 2011/03/15 06:00
PHST- 2010/07/20 00:00 [received]
PHST- 2010/11/16 00:00 [accepted]
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - 10.1002/jso.21829 [doi]
PST - ppublish
SO  - J Surg Oncol. 2011 Apr;103(5):380-5. doi: 10.1002/jso.21829. Epub 2010 Dec 28.