PMID- 21401514
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20191027
IS  - 1875-5453 (Electronic)
IS  - 1389-2002 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Feb
TI  - Role of retinoids, rexinoids and thyroid hormone in the expression of cytochrome 
      p450 enzymes.
PG  - 71-88
AB  - Retinoic acid receptors (RARs), retinoid X receptors (RXRs) and thyroid hormone 
      receptors (TRs) are nuclear receptors that are crucial transcriptional regulators 
      of many cellular processes such as differentiation, development, apoptosis, 
      carbohydrate and lipid metabolism, homeostasis etc. In addition, RXRs are common 
      heterodimerization partners for several receptors including vitamin D receptor, 
      pregnane X receptor (PXR), constitutive androstane receptor (CAR) etc. In the 
      course of 90s', PXR and CAR were discovered as key xenosensors regulating 
      drug-metabolizing enzymes. Since there exist various cross-talks between cell 
      signaling pathways, this was not surprising that RXRs, RARs and TRs were 
      identified as regulators of human drug-metabolizing cytochromes P450 and 
      cytochromes P450 involved in metabolism of endogenous compounds. Hence, a link 
      between regulation of xenobiotic metabolizing enzymes and regulatory pathways of 
      intermediary metabolism was established. Additionally, several drug-metabolizing 
      enzymes are involved in metabolism of retinoids, rexinoids and thyroid hormones. 
      In the current paper, we summarize the knowledge on the role of RARs, RXRs and 
      TRs in the regulation of drug metabolizing cytochromes P450, and vice versa on 
      the role of P450s in homeostasis of retinoids, rexinoids and thyroid hormone.
FAU - Brtko, Julius
AU  - Brtko J
AD  - Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, 
      Slovak Republic. julius.brtko@savba.sk
FAU - Dvorak, Zdenek
AU  - Dvorak Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Curr Drug Metab
JT  - Current drug metabolism
JID - 100960533
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinoids)
RN  - 0 (Thyroid Hormones)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
SB  - IM
MH  - Animals
MH  - Cytochrome P-450 Enzyme System/*genetics/*metabolism/physiology
MH  - Gene Expression Regulation, Enzymologic/*genetics/*radiation effects
MH  - Humans
MH  - Inactivation, Metabolic/genetics/physiology
MH  - Models, Biological
MH  - Receptors, Cytoplasmic and Nuclear/metabolism/physiology
MH  - Receptors, Retinoic Acid/metabolism/physiology
MH  - Receptors, Thyroid Hormone/metabolism/physiology
MH  - Retinoid X Receptors/metabolism/*physiology
MH  - Retinoids/metabolism/*physiology
MH  - Signal Transduction/physiology
MH  - Thyroid Hormones/metabolism/*physiology
EDAT- 2011/03/16 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/03/16 06:00
PHST- 2010/11/06 00:00 [received]
PHST- 2011/02/21 00:00 [accepted]
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - BSP/CDM/E-Pub/000120a [pii]
AID - 10.2174/138920011795016881 [doi]
PST - ppublish
SO  - Curr Drug Metab. 2011 Feb;12(2):71-88. doi: 10.2174/138920011795016881.