PMID- 21401908
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20191210
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 89
IP  - 5
DP  - 2011 Aug
TI  - RNFL thickness in MS-associated acute optic neuritis using SD-OCT: critical 
      interpretation and limitations.
PG  - e451-60
LID - 10.1111/j.1755-3768.2011.02134.x [doi]
AB  - PURPOSE: Axonal loss is considered a key prognostic factor in diagnosing and 
      monitoring the progress of multiple sclerosis (MS). The purpose of our research 
      was to determine whether the measurement of retinal nerve fibre layer thickness 
      (RNFLT) as measured with high-resolution spectral-domain optical coherence 
      tomography (SD-OCT) differs between optic nerve injury following acute optic 
      neuritis (ON) or following unregistered subclinical axonal damage in patients 
      with MS. METHODS: High-resolution SD-OCT measurements of RNFLT were initially 
      carried out in the acute phase of ON and again after 3 months, in 25 patients 
      with clinical definite MS and 25 sex- and age-matched healthy controls, all at 
      the University Eye Hospital, Vienna. RESULTS: Conventional OCT-based RNFLT 
      analysis correctly identified all three patients with initial RNFL swelling. 
      However, only two of three acute ON eyes with a history of ON were registered 
      with RNFLT decrease in seven peripapillary sectors (PPs). The remaining have only 
      been revealed using RNFLT symmetry comparison. Two of 22 (9%) first-episode ON 
      eyes were labelled as pathologic. The number and metric RNFL values of 
      pathologically labelled PPs remained unchanged after 3 months. Our age- and 
      sex-match-based measurement model, with patients with MS being plotted 
      individually and towards the fellow eye, identified all acute ON eyes (with a 
      history of prior ON) with RNFLT reduction in 11 PPs. A global RNFL loss was 
      registered in 36.4% (eight of 22 eyes). However, in 72%, or 16 of 22 ON eyes 
      presenting with first episode of acute ON, a segmental RNFL loss was initially 
      registered in 39 PPs upon baseline examination. The number of PPs with identified 
      axonal decrease increased to a total of 48 PPs within the observational period. 
      CONCLUSIONS: Spectral-domain optical coherence tomography imaging of identical 
      scanning locations, combined with an optimized scan centring around the optic 
      disc, offers the technological potential of detecting prior, subtle, clinically 
      unregistered optic nerve injury within MS individuals. Significant discrepancy in 
      RNFLT to the potential ON eye may be achieved by comparing OCT metrics with the 
      fellow eye and a sufficient number of age and sex-matched controls.
CI  - (c) 2011 The Authors. Acta Ophthalmologica (c) 2011 Acta Ophthalmologica Scandinavica 
      Foundation.
FAU - Serbecic, Nermin
AU  - Serbecic N
AD  - Medical University of Vienna, Department of Ophthalmology, Vienna, Austria. 
      nermin.serbecic@meduniwien.ac.at
FAU - Beutelspacher, Sven C
AU  - Beutelspacher SC
FAU - Geitzenauer, Wolfgang
AU  - Geitzenauer W
FAU - Kircher, Karl
AU  - Kircher K
FAU - Lassmann, Hans
AU  - Lassmann H
FAU - Reitner, Andreas
AU  - Reitner A
FAU - Khan, Adnan
AU  - Khan A
FAU - Schmidt-Erfurth, Ursula
AU  - Schmidt-Erfurth U
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Validation Study
DEP - 20110315
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Acute Disease
MH  - Disease Progression
MH  - Evoked Potentials, Visual/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis, Relapsing-Remitting/*complications/physiopathology
MH  - Optic Nerve/*pathology
MH  - Optic Neuritis/*etiology/*pathology/physiopathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Tomography, Optical Coherence/methods/*standards
MH  - Vision Tests
MH  - Visual Field Tests
EDAT- 2011/03/16 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1111/j.1755-3768.2011.02134.x [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2011 Aug;89(5):e451-60. doi: 10.1111/j.1755-3768.2011.02134.x. 
      Epub 2011 Mar 15.