PMID- 21402057
OWN - NLM
STAT- MEDLINE
DCOM- 20110808
LR  - 20110418
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1388
DP  - 2011 May 4
TI  - Altered gray matter morphometry and resting-state functional and structural 
      connectivity in social anxiety disorder.
PG  - 167-77
LID - 10.1016/j.brainres.2011.03.018 [doi]
AB  - In social anxiety disorder (SAD), impairments in limbic/paralimbic structures are 
      associated with emotional dysregulation and inhibition of the medial prefrontal 
      cortex (MPFC). Little is known, however, about alterations in limbic and frontal 
      regions associated with the integrated morphometric, functional, and structural 
      architecture of SAD. Whether altered gray matter volume is associated with 
      altered functional and structural connectivity in SAD. Three techniques were used 
      with 18 SAD patients and 18 healthy controls: voxel-based morphometry; 
      resting-state functional connectivity analysis; and diffusion tensor imaging 
      tractography. SAD patients exhibited significantly decreased gray matter volumes 
      in the right posterior inferior temporal gyrus (ITG) and right 
      parahippocampal/hippocampal gyrus (PHG/HIP). Gray matter volumes in these two 
      regions negatively correlated with the fear factor of the Liebowitz Social 
      Anxiety Scale. In addition, we found increased functional connectivity in SAD 
      patients between the right posterior ITG and the left inferior occipital gyrus, 
      and between the right PHF/HIP and left middle temporal gyrus. SAD patients had 
      increased right MPFC volume, along with enhanced structural connectivity in the 
      genu of the corpus callosum. Reduced limbic/paralimbic volume, together with 
      increased resting-state functional connectivity, suggests the existence of a 
      compensatory mechanism in SAD. Increased MPFC volume, consonant with enhanced 
      structural connectivity, suggests a long-time overgeneralization of structural 
      connectivity and a role of this area in the mediation of clinical severity. 
      Overall, our results may provide a valuable basis for future studies combining 
      morphometric, functional and anatomical data in the search for a comprehensive 
      understanding of the neural circuitry underlying SAD.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Liao, Wei
AU  - Liao W
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu 610054, PR China.
FAU - Xu, Qiang
AU  - Xu Q
FAU - Mantini, Dante
AU  - Mantini D
FAU - Ding, Jurong
AU  - Ding J
FAU - Machado-de-Sousa, Joao Paulo
AU  - Machado-de-Sousa JP
FAU - Hallak, Jaime E C
AU  - Hallak JE
FAU - Trzesniak, Clarissa
AU  - Trzesniak C
FAU - Qiu, Changjian
AU  - Qiu C
FAU - Zeng, Ling
AU  - Zeng L
FAU - Zhang, Wei
AU  - Zhang W
FAU - Crippa, Jose Alexandre S
AU  - Crippa JA
FAU - Gong, Qiyong
AU  - Gong Q
FAU - Chen, Huafu
AU  - Chen H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110312
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Anxiety Disorders/*pathology
MH  - Brain/*pathology
MH  - *Brain Mapping
MH  - Cross-Sectional Studies
MH  - Diffusion Tensor Imaging
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/*pathology
MH  - Rest
MH  - Social Behavior Disorders/*pathology
MH  - Young Adult
EDAT- 2011/03/16 06:00
MHDA- 2011/08/09 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/02/15 00:00 [received]
PHST- 2011/03/07 00:00 [revised]
PHST- 2011/03/07 00:00 [accepted]
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/08/09 06:00 [medline]
AID - S0006-8993(11)00515-4 [pii]
AID - 10.1016/j.brainres.2011.03.018 [doi]
PST - ppublish
SO  - Brain Res. 2011 May 4;1388:167-77. doi: 10.1016/j.brainres.2011.03.018. Epub 2011 
      Mar 12.