PMID- 21403905
OWN - NLM
STAT- MEDLINE
DCOM- 20110708
LR  - 20211020
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2010
DP  - 2010
TI  - Apocynin improves insulin resistance through suppressing inflammation in high-fat 
      diet-induced obese mice.
PG  - 858735
LID - 10.1155/2010/858735 [doi]
LID - 858735
AB  - We investigated the effects of apocynin on high-fat diet- (HFD-) induced insulin 
      resistance in C57BL/6 mice. After 12 weeks of HFD, the mice that exhibited 
      insulin resistance then received 5 weeks of apocynin (2.4  g/L, in water). 
      Following apocynin treatment, fasting glucose, insulin, and glucose tolerance 
      test showed significant improvement in insulin sensitivity in HFD-fed mice. We 
      demonstrated that serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 
      (IL-6), and leptin were remarkably reduced with apocynin treatment. We also found 
      that mRNA expression of TNF-alpha, IL-6, and monocyte chemoattractant protein-1 
      (MCP-1) in the liver and mRNA expression of TNF-alpha, IL-6, MCP-1, and leptin in 
      adipose tissue were suppressed by apocynin. Furthermore, the activity of 
      transcription factor NF-kappaB in the liver was significantly suppressed with 
      apocynin treatment. These results suggest that apocynin may reduce inflammatory 
      factors in the blood, liver, and adipose tissue, resulting in amelioration of 
      insulin resistance in HFD-fed mice.
FAU - Meng, Ran
AU  - Meng R
AD  - Department of Endocrinology, Nanjing Drum Tower Hospital, Nanjing University 
      School of Medicine, 321 Zhongshan Road, Nanjing 210008, China.
FAU - Zhu, Da-Long
AU  - Zhu DL
FAU - Bi, Yan
AU  - Bi Y
FAU - Yang, Dong-Hui
AU  - Yang DH
FAU - Wang, Ya-Ping
AU  - Wang YP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110221
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Acetophenones)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA Primers)
RN  - 0 (Dietary Fats)
RN  - 0 (IL6 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - B6J7B9UDTR (acetovanillone)
SB  - IM
MH  - Acetophenones/*pharmacology
MH  - Adipose Tissue/drug effects/metabolism
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Antioxidants/pharmacology
MH  - Base Sequence
MH  - Blood Glucose/metabolism
MH  - Chemokine CCL2/genetics/metabolism
MH  - DNA Primers/genetics
MH  - Dietary Fats/administration & dosage
MH  - Disease Models, Animal
MH  - Gene Expression/drug effects
MH  - Glucose Tolerance Test
MH  - Inflammation Mediators/metabolism
MH  - Insulin/blood
MH  - Insulin Resistance/genetics/*physiology
MH  - Interleukin-6/genetics/metabolism
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - NF-kappa B/metabolism
MH  - Obesity/*drug therapy/etiology/genetics/*physiopathology
MH  - RNA, Messenger/genetics/metabolism
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
PMC - PMC3043302
EDAT- 2010/01/01 00:00
MHDA- 2011/07/09 06:00
PMCR- 2011/02/21
CRDT- 2011/03/16 06:00
PHST- 2010/10/27 00:00 [received]
PHST- 2010/12/17 00:00 [accepted]
PHST- 2011/03/16 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/07/09 06:00 [medline]
PHST- 2011/02/21 00:00 [pmc-release]
AID - 10.1155/2010/858735 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2010;2010:858735. doi: 10.1155/2010/858735. Epub 2011 Feb 21.