PMID- 21406036
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20131106
IS  - 1744-7658 (Electronic)
IS  - 1354-3784 (Linking)
VI  - 20
IP  - 5
DP  - 2011 May
TI  - HIF prolyl hydroxylase inhibitors for anemia.
PG  - 645-56
LID - 10.1517/13543784.2011.566861 [doi]
AB  - INTRODUCTION: The hypoxia-inducible factor (HIF) system mediates the body's 
      response to hypoxia, locally, inducing angiogenesis and a shift to anaerobic 
      metabolism, and systemically, increasing red cell mass in anemia. HIF prolyl 
      hydroxylases (HIF-PH) modify HIF, decreasing its activity. Increasing HIF 
      activity through inhibition of HIF-PH may provide an alternative treatment for 
      anemia and may protect against damage related to ischemia-reperfusion. AREAS 
      COVERED: The review discusses the basic science underpinnings of the HIF system 
      and the clinical effects of the HIF system and its pharmacologic manipulation. 
      EXPERT OPINION: Manipulation of the HIF system may improve outcomes in anemia by 
      bypassing the effective iron deficiency found in anemia of chronic disease and by 
      increasing red cell mass without supraphysiologic increases in erythropoietin. 
      HIF-PH may also find a clinical use in the prevention of ischemia-reperfusion 
      damage in strokes, cardiac ischemia, ischemic renal failure, etc.
FAU - Muchnik, Eugene
AU  - Muchnik E
AD  - New Jersey Medical School, Newark, 07103, USA.
FAU - Kaplan, Joshua
AU  - Kaplan J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110316
PL  - England
TA  - Expert Opin Investig Drugs
JT  - Expert opinion on investigational drugs
JID - 9434197
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - EC 1.14.11.2 (Procollagen-Proline Dioxygenase)
SB  - IM
MH  - Anemia/*drug therapy/enzymology
MH  - Animals
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/*antagonists & inhibitors/metabolism
MH  - Myocardial Ischemia/prevention & control
MH  - Myocardial Reperfusion Injury/prevention & control
MH  - Procollagen-Proline Dioxygenase/*antagonists & inhibitors/metabolism
EDAT- 2011/03/17 06:00
MHDA- 2011/07/28 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
AID - 10.1517/13543784.2011.566861 [doi]
PST - ppublish
SO  - Expert Opin Investig Drugs. 2011 May;20(5):645-56. doi: 
      10.1517/13543784.2011.566861. Epub 2011 Mar 16.