PMID- 21409535
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20240505
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 27
IP  - 2
DP  - 2011 Feb
TI  - Utilization of frequency domain optical coherence tomography and fractional flow 
      reserve to assess intermediate coronary artery stenoses: conciliating anatomic 
      and physiologic information.
PG  - 299-308
LID - 10.1007/s10554-011-9847-9 [doi]
AB  - Fractional flow reserve (FFR) and intravascular imaging respectively provide 
      hemodynamic and anatomical assessments of angiographic intermediate stenoses. 
      Frequency domain optical coherence tomography (FD-OCT) is a promising 
      high-resolution imaging modality, but its clinical use in determining severity of 
      coronary disease has yet to be determined. There, we set out to determine the 
      role of FD-OCT to complement FFR in the evaluation of intermediate coronary 
      artery stenoses. FD-OCT was planned in 176 consecutive interventional procedures 
      at our institution to delineate the proper use of FD-OCT in clinical practice. 
      The decision to use other invasive assessments was at the discretion of the 
      operator. This report describes an early series of the 14 patients who underwent 
      FFR of 18 target stenoses in addition to FD-OCT. FD-OCT was successfully 
      performed without complications in all cases. Fractional flow reserve was <0.80 
      in four patients, with minimal lumen areas and reference vessel diameters ranging 
      from 1.03 to 3.47 mm(2) and 2.60 to 2.94 mm by FD-OCT, respectively. FD-OCT was 
      important to rule out plaque rupture, erosion and thrombosis and to help guide 
      decision to defer PCI in six patients with acute coronary syndrome and FFR > 
      0.80. FD-OCT was also valuable to guide PCI strategy in tandem lesions with an 
      FFR < 0.80. This initial experience with FD-OCT suggests a potential 
      complementary role of physiological and anatomical assessment to guide decision 
      making in complex clinical scenarios. Future investigations are warranted to 
      validate these findings and define the role of FD-OCT in assessing intermediate 
      lesions.
FAU - Stefano, Gregory T
AU  - Stefano GT
AD  - Harrington-McLaughlin Heart and Vascular Institute, Cardiovascular Imaging Core 
      Laboratory, University Hospitals Case Medical Center, Case Western Reserve 
      University School of Medicine, Cleveland, OH 44106-5038, USA.
FAU - Bezerra, Hiram G
AU  - Bezerra HG
FAU - Attizzani, Guilherme
AU  - Attizzani G
FAU - Chamie, Daniel
AU  - Chamie D
FAU - Mehanna, Emile
AU  - Mehanna E
FAU - Yamamoto, Hirosada
AU  - Yamamoto H
FAU - Costa, Marco A
AU  - Costa MA
LA  - eng
GR  - R01 HL114406/HL/NHLBI NIH HHS/United States
GR  - R21 HL108263/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110317
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Vasodilator Agents)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine
MH  - Adult
MH  - Aged
MH  - *Cardiac Catheterization/statistics & numerical data
MH  - Coronary Angiography
MH  - Coronary Stenosis/*diagnosis/pathology/physiopathology
MH  - Female
MH  - *Fractional Flow Reserve, Myocardial
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ohio
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Severity of Illness Index
MH  - *Tomography, Optical Coherence/statistics & numerical data
MH  - Vasodilator Agents
PMC - PMC3984934
MID - NIHMS358848
EDAT- 2011/03/17 06:00
MHDA- 2011/08/10 06:00
PMCR- 2014/04/13
CRDT- 2011/03/17 06:00
PHST- 2011/02/17 00:00 [received]
PHST- 2011/02/19 00:00 [accepted]
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
PHST- 2014/04/13 00:00 [pmc-release]
AID - 10.1007/s10554-011-9847-9 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2011 Feb;27(2):299-308. doi: 10.1007/s10554-011-9847-9. 
      Epub 2011 Mar 17.