PMID- 21410655
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20110519
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 77
IP  - 6
DP  - 2011 Jun
TI  - Antibody-reactive epitope determination with HLAMatchmaker and its clinical 
      applications.
PG  - 525-34
LID - 10.1111/j.1399-0039.2011.01646.x [doi]
AB  - Antibodies against allogeneic human leukocyte antigen (HLA) molecules are 
      important impediments to the success of different clinical procedures including 
      transplantation and platelet transfusion. In these settings, characterization of 
      the repertoire of immunogenic epitopes is important for permissible mismatch 
      determination and the identification of acceptable mismatches for sensitized 
      patients. HLAMatchmaker is a computer algorithm that considers small 
      configurations of polymorphic residues referred to as eplets as essential 
      components of HLA epitopes. This review critically elaborates the concepts 
      underlying the HLAMatchmaker and describes the usefulness of HLAMatchmaker in the 
      clinical setting. Recent developments have increased our understanding of 
      structural basis of HLA antigenicity (i.e. reactivity with specific antibody) and 
      immunogenicity (i.e. its ability to induce an antibody response).
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Duquesnoy, R J
AU  - Duquesnoy RJ
AD  - Division of Transplantation Pathology, Thomas E. Starzl Transplantation 
      Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. 
      Duquesnoyr@upmc.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110317
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Algorithms
MH  - Blood Group Incompatibility
MH  - Blood Platelets/metabolism
MH  - Blood Transfusion
MH  - Corneal Transplantation/methods
MH  - Epitopes/*chemistry
MH  - HLA Antigens/chemistry/*immunology
MH  - Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Kidney Transplantation/methods
MH  - Phenotype
MH  - Protein Conformation
MH  - Risk Factors
MH  - Transplantation/*methods
EDAT- 2011/03/18 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01646.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Jun;77(6):525-34. doi: 10.1111/j.1399-0039.2011.01646.x. 
      Epub 2011 Mar 17.