PMID- 21411354
OWN - NLM
STAT- MEDLINE
DCOM- 20110822
LR  - 20221207
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 15
IP  - 5
DP  - 2011 May
TI  - Association of the HLA-DRB1 locus with syphilis in a Chinese population.
PG  - e342-5
LID - 10.1016/j.ijid.2011.01.008 [doi]
AB  - BACKGROUND: Syphilis is a sexually transmitted infection (STI) caused by the 
      Treponema pallidum subspecies pallidum spirochete bacterium. The association of 
      human leukocyte antigen (HLA) with syphilis has been reported in several 
      populations, but not in the Chinese population. Furthermore, serology methods 
      have mostly been used in previous studies investigating the association between 
      STIs and HLA alleles. The objective of this study was to analyze the association 
      of the HLA-DRB1 alleles and susceptibility to syphilis in the Chinese population. 
      METHODS: A polymerase chain reaction with sequence-specific primers (PCR-SSP) 
      method was used to genotype HLA-DRB1 alleles in 196 syphilis patients and 500 
      healthy controls. RESULTS: The HLA-DRB1*14 allele was more prevalent in syphilis 
      patients than in the healthy controls (p=0.013; corrected p<0.05). CONCLUSIONS: 
      The allele HLA-DRB1*14 was found to be associated with susceptibility to syphilis 
      in the Chinese population.
CI  - Copyright (c) 2011 International Society for Infectious Diseases. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Jiang, Hong-Wei
AU  - Jiang HW
AD  - Shandong Provincial Institute of Dermatology and Venereology, Provincial Academy 
      of Medical Science, Shandong Province, China.
FAU - Tian, Hong-Qing
AU  - Tian HQ
FAU - Liu, Hong
AU  - Liu H
FAU - Li, Na
AU  - Li N
FAU - Zhao, Yi
AU  - Zhao Y
FAU - Zhang, Fu-Ren
AU  - Zhang FR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110315
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease/genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Prevalence
MH  - Syphilis/*genetics/immunology
MH  - Treponema pallidum/immunology/pathogenicity
MH  - Young Adult
EDAT- 2011/03/18 06:00
MHDA- 2011/08/23 06:00
CRDT- 2011/03/18 06:00
PHST- 2010/09/21 00:00 [received]
PHST- 2011/01/14 00:00 [revised]
PHST- 2011/01/17 00:00 [accepted]
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/08/23 06:00 [medline]
AID - S1201-9712(11)00025-7 [pii]
AID - 10.1016/j.ijid.2011.01.008 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2011 May;15(5):e342-5. doi: 10.1016/j.ijid.2011.01.008. Epub 
      2011 Mar 15.