PMID- 21411384
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20221207
IS  - 1579-2021 (Electronic)
IS  - 1575-0922 (Linking)
VI  - 58
IP  - 4
DP  - 2011 Apr
TI  - Microvascular complications and risk factors in patients with type 2 diabetes.
PG  - 163-8
LID - 10.1016/j.endonu.2011.01.006 [doi]
AB  - AIM: To conduct a prospective study in patients with type 2 diabetes mellitus 
      (T2DM) with no microvascular complications, analyzing the association between 
      various baseline risk factors and development of microvascular complications at 
      follow-up. METHODS: A prospective, observational study in 376 patients with T2DM 
      enrolled in 2004. The clinical end-point was urinary albumin excretion (UAE) > 
      30mg/24h and/or presence of retinopathy at follow-up in 2007. Baseline variables 
      included age, gender, duration of T2DM, fasting plasma glucose, glycated 
      hemoglobin (HbA(1c)), systolic and diastolic blood pressure, body weight, height, 
      body mass index, waist circumference, total cholesterol, triglycerides, high 
      density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol 
      (LDL-C), high sensitive C-reactive protein (hs-CRP), fibrinogen, UAE, creatinine, 
      smoking status, exercise, alcohol consumption, use of hypoglycemic and 
      lipid-lowering drugs, antihypertensive medications, and other data related to 
      family history of diabetes and risk factors. RESULTS: Ninety-five subjects 
      (25.2%) developed a microvascular complication at the end of the follow-up 
      period. In logistic regression analyses, the main independent risk factors were 
      UAE >12mg/24h (odds ratio [OR]: 6.12; P=.000), hs-CRP> 3mg/L (OR: 3.00; P=.004), 
      and hypertension (OR: 2.43; P=.023). CONCLUSIONS: UAE levels higher than 
      12mg/24h, hs-CRP >3mg/L, and presence of hypertension were all independent risk 
      factors for development of microvascular complications in patients with T2DM 
      studied.
CI  - Copyright (c) 2010 SEEN. Published by Elsevier Espana. All rights reserved.
FAU - Del Canizo Gomez, Francisco Javier
AU  - Del Canizo Gomez FJ
AD  - Section of Endocrinology and Nutrition, Hospital Universitario Infanta Leonor, 
      School of Medicine, Universidad Complutense, Madrid, Spain. 
      fjdelcanizogomez@hotmail.com
FAU - Fernandez Perez, Cristina
AU  - Fernandez Perez C
FAU - Moreno Ruiz, Inmaculada
AU  - Moreno Ruiz I
FAU - de Gorospe Perez-Jauregui, Carlos
AU  - de Gorospe Perez-Jauregui C
FAU - Silveira Rodriguez, Belen
AU  - Silveira Rodriguez B
FAU - Gonzalez Losada, Tomas
AU  - Gonzalez Losada T
FAU - Segura Galindo, Amparo
AU  - Segura Galindo A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110315
PL  - Spain
TA  - Endocrinol Nutr
JT  - Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y 
      Nutricion
JID - 100886482
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Lipids)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Albuminuria/epidemiology/etiology
MH  - Anthropometry
MH  - Antihypertensive Agents/therapeutic use
MH  - Blood Glucose/analysis
MH  - C-Reactive Protein/analysis
MH  - Diabetes Mellitus, Type 2/*complications/drug therapy/epidemiology/genetics
MH  - Diabetic Angiopathies/*epidemiology
MH  - Diabetic Nephropathies/*epidemiology
MH  - Diabetic Retinopathy/*epidemiology
MH  - Female
MH  - Fibrinogen/analysis
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin/analysis
MH  - Habits
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Lipids/blood
MH  - Male
MH  - *Microcirculation
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
EDAT- 2011/03/18 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/03/18 06:00
PHST- 2010/09/08 00:00 [received]
PHST- 2011/01/07 00:00 [revised]
PHST- 2011/01/24 00:00 [accepted]
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - S1575-0922(11)00062-3 [pii]
AID - 10.1016/j.endonu.2011.01.006 [doi]
PST - ppublish
SO  - Endocrinol Nutr. 2011 Apr;58(4):163-8. doi: 10.1016/j.endonu.2011.01.006. Epub 
      2011 Mar 15.