PMID- 21411969
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20210105
IS  - 1662-8128 (Electronic)
IS  - 1662-811X (Linking)
VI  - 3
IP  - 3
DP  - 2011
TI  - The bidirectional crosstalk between human dendritic cells and natural killer 
      cells.
PG  - 258-63
LID - 10.1159/000323923 [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells, which display an 
      extraordinary capacity to induce T-cell responses. Recent findings revealed that 
      DCs also play a crucial role in the activation of natural killer (NK) cells 
      representing important effectors in the innate immune defense against viruses and 
      tumors. Here, we summarize various studies investigating the bidirectional 
      crosstalk between human DCs and NK cells. In this context, it has been reported 
      that DCs efficiently enhance CD69 expression, proliferation, interferon (IFN)-gamma 
      secretion and cytotoxic activity of NK cells. Cell membrane-associated molecules 
      as well as soluble factors such as interleukin-12, tumor necrosis factor-alpha and 
      type I IFNs contributed to DC-mediated NK cell activation. Reciprocally, the 
      ability of human NK cells to enhance the immunostimulatory capacity of DCs was 
      shown. Thus, NK cells promoted the maturation of DCs and markedly augmented their 
      capacity to produce proinflammatory cytokines and to stimulate T-cell responses. 
      The NK cell-mediated effects on DCs were dependent on cell membrane-associated 
      molecules such as NKp30 and soluble factors such as tumor necrosis factor-alpha and 
      IFN-gamma. In conclusion, the reciprocal activating interaction between human DCs and 
      NK cells may play a pivotal role in the immune defense against viruses and 
      tumors.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Wehner, Rebekka
AU  - Wehner R
AD  - Institute of Immunology, Medical Faculty, Technical University of Dresden, 
      Dresden, Germany.
FAU - Dietze, Kristin
AU  - Dietze K
FAU - Bachmann, Michael
AU  - Bachmann M
FAU - Schmitz, Marc
AU  - Schmitz M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110311
PL  - Switzerland
TA  - J Innate Immun
JT  - Journal of innate immunity
JID - 101469471
RN  - 0 (Cytokines)
RN  - 0 (NCR3 protein, human)
RN  - 0 (Natural Cytotoxicity Triggering Receptor 3)
SB  - IM
MH  - Antigen Presentation
MH  - Cell Communication/*immunology
MH  - Cell Differentiation
MH  - Cytokines/*immunology
MH  - Cytotoxicity, Immunologic
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunity, Innate
MH  - Killer Cells, Natural/*immunology
MH  - Lymphocyte Activation
MH  - Natural Cytotoxicity Triggering Receptor 3/immunology
EDAT- 2011/03/18 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/03/18 06:00
PHST- 2010/10/21 00:00 [received]
PHST- 2010/12/07 00:00 [accepted]
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - 000323923 [pii]
AID - 10.1159/000323923 [doi]
PST - ppublish
SO  - J Innate Immun. 2011;3(3):258-63. doi: 10.1159/000323923. Epub 2011 Mar 11.