PMID- 21411985
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20171116
IS  - 1421-9662 (Electronic)
IS  - 0001-5792 (Linking)
VI  - 126
IP  - 1
DP  - 2011
TI  - Expansion of CD56-negative, CD16-positive, KIR-expressing natural killer cells 
      after T cell-depleted haploidentical hematopoietic stem cell transplantation.
PG  - 13-20
LID - 10.1159/000323661 [doi]
AB  - The main functions of natural killer (NK) cells are early protection against 
      viruses or tumor cells and production of cytokines that regulate immune 
      functions. The present study assessed the role of different NK subsets in 
      exerting graft-versus-leukemia effects in recipients of human leukocyte antigen 
      (HLA) haploidentical hematopoietic transplants and monitored for the first time 
      CD3-/CD56- lymphocyte expansion. CD3-/CD56- cells expressed NK cell-associated 
      molecules, such as CD16, NKp46, NKp30, CD244 (2B4), CD161, and killer cell 
      immunoglobulin-like receptors. CD3-/CD56- cells further exhibited the classical 
      functional characteristics of NK cells: cytolysis of target cells lacking HLA 
      class I, antibody-dependent cellular cytotoxicity and cytokine production. These 
      results demonstrate that CD56- NK cells are functional, recognize missing self 
      and, like their CD56+ counterparts, may contribute to graft-versus-leukemia 
      reactions.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - De Angelis, Claudia
AU  - De Angelis C
AD  - Division of Hematology and Clinical Immunology, Department of Clinical and 
      Experimental Medicine, University of Perugia, Perugia, Italy.
FAU - Mancusi, Antonella
AU  - Mancusi A
FAU - Ruggeri, Loredana
AU  - Ruggeri L
FAU - Capanni, Marusca
AU  - Capanni M
FAU - Urbani, Elena
AU  - Urbani E
FAU - Velardi, Andrea
AU  - Velardi A
FAU - Stern, Martin
AU  - Stern M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110317
PL  - Switzerland
TA  - Acta Haematol
JT  - Acta haematologica
JID - 0141053
RN  - 0 (CD56 Antigen)
RN  - 0 (Receptors, IgG)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Antibody-Dependent Cell Cytotoxicity
MH  - CD56 Antigen/*immunology
MH  - Flow Cytometry
MH  - Hematologic Neoplasms/immunology/*surgery
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Immunophenotyping
MH  - Killer Cells, Natural/*immunology/metabolism
MH  - *Lymphocyte Depletion
MH  - Receptors, IgG/*immunology
MH  - Receptors, KIR/*metabolism
EDAT- 2011/03/18 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/03/18 06:00
PHST- 2010/12/20 00:00 [accepted]
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 000323661 [pii]
AID - 10.1159/000323661 [doi]
PST - ppublish
SO  - Acta Haematol. 2011;126(1):13-20. doi: 10.1159/000323661. Epub 2011 Mar 17.