PMID- 21411999
OWN - NLM
STAT- MEDLINE
DCOM- 20110808
LR  - 20110413
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 118
IP  - 1
DP  - 2011
TI  - The role of the immunogenetic background in the development and recurrence of 
      acute idiopathic pericarditis.
PG  - 55-62
LID - 10.1159/000324309 [doi]
AB  - OBJECTIVES: We assessed the role of the immunogenetic background in the 
      development and recurrence of acute idiopathic pericarditis (AIP). METHODS: 
      Fifty-five patients with a first episode of AIP were followed for 23.8 +/- 6.3 
      months and recurrences were recorded. The control group consisted of 246 healthy 
      individuals. In all subjects, genomic human leukocyte antigen (HLA) typing was 
      performed. Moreover, circulating lymphocyte subpopulations were studied in 44 
      randomly selected patients and in 20 controls. RESULTS: An increased frequency of 
      HLA-A*02, -Cw*07 and -DQB1*0202 alleles, and a decreased frequency of the 
      -DQB1*0302 allele was detected in patients with AIP. The recurrence rate was 40% 
      and time to recurrence was 202.8 +/- 164.1 days. In patients with idiopathic 
      recurrent pericarditis (RP), increased frequencies of HLA-A*02, -Cw*07 and 
      -DQB1*0202 alleles were found. Notably, no patient with RP exhibited HLA-DRB1*04 
      and -DQB1*0302 alleles. Patients with RP exhibited lower CD4+/CD45RA+ naive T 
      cells (p = 0.03) than controls, and higher CD8+DR+ activated T cells (p = 0.01) 
      than patients without recurrence and controls. CONCLUSIONS: HLA alleles may 
      confer either susceptibility or resistance to AIP and RP. Circulating T-cell 
      subpopulations may also predict RP. A combination of the above parameters might 
      help to better define patients prone to recurrence.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Lazaros, George
AU  - Lazaros G
AD  - First Department of Cardiology, Hippokration Hospital, University of Athens, 
      Athens, Greece. glaz35@hotmail.com
FAU - Karavidas, Apostolos
AU  - Karavidas A
FAU - Spyropoulou, Maria
AU  - Spyropoulou M
FAU - Tsiachris, Dimitrios
AU  - Tsiachris D
FAU - Halapas, Antonios
AU  - Halapas A
FAU - Zacharoulis, Achilleas
AU  - Zacharoulis A
FAU - Arapi, Sophia
AU  - Arapi S
FAU - Matzaraki, Vasiliki
AU  - Matzaraki V
FAU - Papadopoulos, Kostantinos
AU  - Papadopoulos K
FAU - Korres, Dimitrios
AU  - Korres D
FAU - Iniotaki, Aliki
AU  - Iniotaki A
FAU - Pyrgakis, Vlassis
AU  - Pyrgakis V
FAU - Stefanadis, Christodoulos
AU  - Stefanadis C
LA  - eng
PT  - Journal Article
DEP - 20110317
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Immunophenotyping
MH  - Male
MH  - Middle Aged
MH  - Pericarditis/genetics/*immunology
MH  - Recurrence
MH  - T-Lymphocyte Subsets
EDAT- 2011/03/18 06:00
MHDA- 2011/08/09 06:00
CRDT- 2011/03/18 06:00
PHST- 2010/12/07 00:00 [received]
PHST- 2011/01/08 00:00 [accepted]
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/08/09 06:00 [medline]
AID - 000324309 [pii]
AID - 10.1159/000324309 [doi]
PST - ppublish
SO  - Cardiology. 2011;118(1):55-62. doi: 10.1159/000324309. Epub 2011 Mar 17.