PMID- 2141221
OWN - NLM
STAT- MEDLINE
DCOM- 19900713
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 119
IP  - 6
DP  - 1990 Jun
TI  - Iodine-123 phenylpentadecanoic acid myocardial scintigraphy in patients with left 
      ventricular hypertrophy: alterations in left ventricular distribution and 
      utilization.
PG  - 1338-47
AB  - Regional alterations in myocardial substrate uptake and/or utilization have been 
      demonstrated in rats with hypertension. To determine whether alterations in left 
      ventricular fatty acid uptake and/or utilization are present in patients with 
      left ventricular hypertrophy (LVH), we compared the results of rest and exercise 
      iodine-123 phenylpentadecanoic acid (IPPA) myocardial scintigraphy in 10 patients 
      with hypertension who had concentric LVH without evidence of coronary artery 
      disease and in 15 normal subjects. Patients with LVH had more heterogeneous left 
      ventricular activity of IPPA compared to normal subjects after exercise but not 
      at rest (23 +/- 8% versus 13 +/- 5% difference in maximum segmental activity at 4 
      minutes after exercise; p = 0.005). Although IPPA clearance was similar in both 
      patients with LVH and normal subjects, postexercise washout in segments showing 
      decreased initial IPPA uptake was reduced compared to washout at rest in patients 
      with LVH (11.7 +/- 7.5% versus 21.5 +/- 8.4% at 20 minutes after injection, n = 
      15; p = 0.005). Exercise thallium-201 (TI-201) scintigraphy was normal in all 
      seven patients with LVH tested. Patients with LVH showed significantly greater 
      heterogeneity in IPPA uptake compared to TI-201 uptake immediately after exercise 
      (25 +/- 5% versus 16 +/- 6%; p = 0.013). We conclude that (1) compared to normal 
      subjects, patients with LVH show heterogeneous myocardial IPPA activity after 
      exercise but not at rest; (2) postexercise washout of IPPA was decreased in 
      segments with reduced uptake after exercise in patients with LVH; and (3) the 
      distribution of IPPA is more heterogeneous than that of TI-201 immediately after 
      exercise in patients with concentric LVH. The postexercise heterogeneity in IPPA 
      uptake and delayed washout in segments with reduced initial uptake is consistent 
      with exercise-induced myocardial ischemia in patients with LVH.
FAU - Wolfe, C L
AU  - Wolfe CL
AD  - Department of Internal Medicine, University of Texas Health Science Center.
FAU - Kennedy, P L
AU  - Kennedy PL
FAU - Kulkarni, P V
AU  - Kulkarni PV
FAU - Jansen, D E
AU  - Jansen DE
FAU - Gabliani, G I
AU  - Gabliani GI
FAU - Corbett, J R
AU  - Corbett JR
LA  - eng
GR  - HL 17669/HL/NHLBI NIH HHS/United States
GR  - HL-01972-03/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Iodobenzenes)
RN  - 0 (Thallium Radioisotopes)
RN  - 80479-93-2 (omega-(4-iodophenyl)pentadecanoic acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomegaly/*diagnostic imaging
MH  - Electrocardiography
MH  - Exercise Test
MH  - Female
MH  - Heart/*diagnostic imaging
MH  - Heart Ventricles
MH  - Humans
MH  - Iodine Radioisotopes
MH  - *Iodobenzenes/pharmacokinetics
MH  - Male
MH  - Middle Aged
MH  - Myocardium/metabolism
MH  - Radionuclide Imaging
MH  - Thallium Radioisotopes/pharmacokinetics
MH  - Tissue Distribution
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
AID - S0002-8703(05)80184-X [pii]
AID - 10.1016/s0002-8703(05)80184-x [doi]
PST - ppublish
SO  - Am Heart J. 1990 Jun;119(6):1338-47. doi: 10.1016/s0002-8703(05)80184-x.