PMID- 21412248
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20220318
IS  - 1435-232X (Electronic)
IS  - 1434-5161 (Linking)
VI  - 56
IP  - 6
DP  - 2011 Jun
TI  - HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased 
      risk of developing psoriasis: evidence of gene interaction.
PG  - 423-7
LID - 10.1038/jhg.2011.33 [doi]
AB  - Psoriasis is an inflammatory skin disorder that exhibits multifactorial mode of 
      inheritance. In addition to the well-known susceptibility locus PSORS1 many other 
      loci have been shown to be implicated in the genetic predisposition for disease. 
      However, interactions between loci have not been thoroughly explored. Thus, we 
      measured the effect of potential interaction between human leukocyte antigen 
      (HLA)-C, CSTA and D1S236 at PSORS1, PSORS4 and PSORS5, respectively, in the 
      development of psoriasis. Analysis of 130 Caucasian psoriatic families showed 
      that the risk to an HLA-Cw6 +ve individual who carries two copies of the risk 
      allele at both the CSTA and D1S2346 is 105 times the risk to an HLA-Cw6 +ve 
      individual who does not carry any risk alleles at the CSTA or D1S2346. This is 
      the first demonstration of an interaction between risk alleles in three 
      susceptibility loci suggesting possible functional interaction between genes in 
      these loci, which might explain the complexity of the pathogenesis of psoriasis.
FAU - Vasilopoulos, Yiannis
AU  - Vasilopoulos Y
AD  - The Medical School, University of Sheffield, Sheffield, UK. 
      iovasilopoulos@bio.uth.gr
FAU - Sagoo, Gurdeep S
AU  - Sagoo GS
FAU - Cork, Michael J
AU  - Cork MJ
FAU - Walters, Kevin
AU  - Walters K
FAU - Tazi-Ahnini, Rachid
AU  - Tazi-Ahnini R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110317
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (CARD Signaling Adaptor Proteins)
RN  - 0 (Cystatin A)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*06 antigen)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - 80209-89-8 (CSTA protein, human)
RN  - EC 4.6.1.- (CARD14 protein, human)
RN  - EC 4.6.1.2 (Guanylate Cyclase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Alleles
MH  - CARD Signaling Adaptor Proteins
MH  - Child
MH  - Child, Preschool
MH  - Cystatin A/*genetics
MH  - Epistasis, Genetic/genetics
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Guanylate Cyclase
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Membrane Proteins
MH  - Microsatellite Repeats/genetics
MH  - Middle Aged
MH  - Proteins/*genetics/metabolism
MH  - Psoriasis/*genetics
MH  - Risk
MH  - Young Adult
EDAT- 2011/03/18 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - jhg201133 [pii]
AID - 10.1038/jhg.2011.33 [doi]
PST - ppublish
SO  - J Hum Genet. 2011 Jun;56(6):423-7. doi: 10.1038/jhg.2011.33. Epub 2011 Mar 17.