PMID- 21412789
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110317
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 83
IP  - 5
DP  - 2011 May
TI  - Case report: a case of light chain deposition disease involving liver and stomach 
      with chronic hepatitis C virus infection and hepatocellular carcinoma.
PG  - 810-4
LID - 10.1002/jmv.22050 [doi]
AB  - Light chain deposition disease (LCDD) is a rare, plasma cell proliferative 
      disorder characterized by mainly abnormal light chain deposition in various 
      organs. Hepatitis C virus (HCV) is a hepatotrophic and lymphotrophic virus and 
      significantly related to B-cell proliferation. This is a case report of systemic 
      LCDD involving liver, stomach, bone marrow, and probably kidney, in a patient 
      with HCV-related hepatocellular carcinoma (HCC). A 62-year-old man with chronic 
      HCV infection who presented with a small HCC in segment 8 of the liver and 
      nephrotic syndrome showed kappa typed immunoglobulin light chain depositions in 
      biopsy specimens of bone marrow, stomach, and non-tumorous liver parenchyma. 
      After treatment of the HCC with transarterial chemoembolization, antiviral 
      therapy for chronic hepatitis C was started. The patient showed early virologic 
      response at 12 weeks of treatment; however, antiviral therapy was discontinued 
      due to adverse effects and he was lost to follow-up. This is the first case of 
      LCDD involving the liver and stomach in a patient with chronic HCV infection and 
      HCC, which may represent LCDD as a rare HCV-associated B cell proliferative 
      disease.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Kwon, Jung Hee
AU  - Kwon JH
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital, 
      Gumi-dong, Seongnam-si, Korea.
FAU - Jeong, Sook-Hyang
AU  - Jeong SH
FAU - Kim, Jin-Wook
AU  - Kim JW
FAU - Bang, Soo-Mee
AU  - Bang SM
FAU - Kim, Haeryoung
AU  - Kim H
FAU - Kim, Young Hoon
AU  - Kim YH
FAU - Song, Sang Hoon
AU  - Song SH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Antibodies, Monoclonal)
SB  - IM
MH  - Antibodies, Monoclonal/*metabolism
MH  - Bone Marrow
MH  - Carcinoma, Hepatocellular/complications/*diagnosis/pathology
MH  - Hepatitis C, Chronic/complications/*diagnosis/pathology
MH  - Histocytochemistry
MH  - Humans
MH  - Immunohistochemistry
MH  - Liver/pathology
MH  - Liver Neoplasms/complications/*diagnosis/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Microscopy
MH  - Middle Aged
MH  - Radiography, Abdominal
MH  - Stomach/pathology
EDAT- 2011/03/18 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 10.1002/jmv.22050 [doi]
PST - ppublish
SO  - J Med Virol. 2011 May;83(5):810-4. doi: 10.1002/jmv.22050.