PMID- 21412921
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20220329
IS  - 1469-493X (Electronic)
IS  - 1361-6137 (Linking)
VI  - 2011
IP  - 3
DP  - 2011 Mar 16
TI  - Haematological interventions for treating disseminated intravascular coagulation 
      during pregnancy and postpartum.
PG  - CD008577
LID - 10.1002/14651858.CD008577.pub2 [doi]
LID - CD008577
AB  - BACKGROUND: Disseminated intravascular coagulation (DIC) is an acquired syndrome 
      characterised by systemic intravascular activation of coagulation. There are 
      several obstetric causes of DIC during pregnancy and postpartum. OBJECTIVES: To 
      assess the clinical effectiveness and safety of haematological interventions such 
      as heparins (low molecular weight heparin (LMWH) and unfractionated heparin 
      (UFH), danaparoid sodium, synthetic protease inhibitor, antithrombin, human 
      recombinant activated protein C, recombinant human soluble thrombomodulin, 
      recombinant tissue factor pathway inhibitor, recombinant activated factor VIIa 
      and any other types of haematological interventions (except transfusions) for 
      treating DIC during pregnancy and postpartum. SEARCH STRATEGY: We searched the 
      Cochrane Pregnancy and Childbirth Group's Trials Register (27 July 2010), LILACS 
      (1982 to 22 July 2010), ongoing trials registries via the World Health 
      Organization International Clinical Trials Platform Search Portal (22 July 2010), 
      and other relevant websites (22 July 2010). SELECTION CRITERIA: Randomised 
      controlled trials (RCTs) on any haematological interventions for treating DIC 
      during pregnancy and postpartum. DATA COLLECTION AND ANALYSIS: There were no 
      included studies. MAIN RESULTS: We could not find any RCTs on haematological 
      interventions (heparins (LMWH and UFH), danaparoid sodium, synthetic protease 
      inhibitor, antithrombin, human recombinant activated protein C, recombinant human 
      soluble thrombomodulin, recombinant tissue factor pathway inhibitor, recombinant 
      activated factor VIIa and any other types of haematological interventions) for 
      treating DIC during pregnancy and postpartum. AUTHORS' CONCLUSIONS: This review 
      found no RCTs on the safety and efficacy of haematological interventions for 
      treating DIC during pregnancy and postpartum. Such interventions need to be 
      tested in RCTs assessing outcomes such as maternal death, perinatal death and 
      safety.
FAU - Marti-Carvajal, Arturo J
AU  - Marti-Carvajal AJ
AD  - Iberoamerican Cochrane Network, Valencia, Edo. Carabobo, Venezuela, 2001.
FAU - Comunian-Carrasco, Gabriella
AU  - Comunian-Carrasco G
FAU - Pena-Marti, Guiomar E
AU  - Pena-Marti GE
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20110316
PL  - England
TA  - Cochrane Database Syst Rev
JT  - The Cochrane database of systematic reviews
JID - 100909747
SB  - IM
UOF - doi: 10.1002/14651858.CD008577
MH  - Disseminated Intravascular Coagulation/*drug therapy
MH  - Female
MH  - Humans
MH  - Postpartum Period
MH  - Pregnancy
MH  - Pregnancy Complications, Hematologic/*drug therapy
PMC - PMC8947843
COIS- In 2004, Arturo Marti-Carvajal was employed by Eli Lilly to run a four-hour 
      workshop on 'how to critically appraise clinical trials on osteoporosis and how 
      to teach this'. This activity was not related to his work with The Cochrane 
      Collaboration or any Cochrane review. In 2007, Arturo Marti-Carvajal was employed 
      by Merck to run a four-hour workshop 'how to critically appraise clinical trials 
      and how to teach this'. This activity was not related to his work with The 
      Cochrane Collaboration or any Cochrane review. Guiomar Pena-Marti and Gabriella 
      Comunian-Carrasco: none known.
EDAT- 2011/03/18 06:00
MHDA- 2011/04/02 06:00
PMCR- 2012/03/16
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
PHST- 2012/03/16 00:00 [pmc-release]
AID - CD008577.pub2 [pii]
AID - 10.1002/14651858.CD008577.pub2 [doi]
PST - epublish
SO  - Cochrane Database Syst Rev. 2011 Mar 16;2011(3):CD008577. doi: 
      10.1002/14651858.CD008577.pub2.