PMID- 21415124
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20151119
IS  - 1942-0080 (Electronic)
IS  - 1941-9651 (Linking)
VI  - 4
IP  - 3
DP  - 2011 May
TI  - Late gadolinium enhancement magnetic resonance imaging in the diagnosis and 
      prognosis of endomyocardial fibrosis patients.
PG  - 304-11
LID - 10.1161/CIRCIMAGING.110.950675 [doi]
AB  - BACKGROUND: Endocardial fibrous tissue (FT) deposition is a hallmark of 
      endomyocardial fibrosis (EMF). Echocardiography is a first-line and the standard 
      technique for the diagnosis of this disease. Although late gadolinium enhancement 
      (LGE) cardiovascular magnetic resonance (CMR) allows FT characterization, its 
      role in the diagnosis and prognosis of EMF has not been investigated. METHODS AND 
      RESULTS: Thirty-six patients (29 women; age, 54+/-12 years) with EMF diagnosis 
      after clinical evaluation and comprehensive 2-dimensional Doppler 
      echocardiography underwent cine-CMR for assessing ventricular volumes, ejection 
      fraction and mass, and LGE-CMR for FT characterization and quantification. 
      Indexed FT volume (FT/body surface area) was calculated after planimetry of the 8 
      to 12 slices obtained in the short-axis view at end-diastole (mL/m(2)). Surgical 
      resection of FT was performed in 16 patients. In all patients, areas of LGE were 
      confined to the endocardium, frequently as a continuous streak from the inflow 
      tract extending to the apex, where it was usually most prominent. There was a 
      relation between increased FT/body surface area and worse New York Heart 
      Association functional class and with increased probability of surgery (P<0.05). 
      The histopathologic examination of resected FT showed typical features of EMF 
      with extensive endocardial fibrous thickening, proliferation of small vessels, 
      and scarce inflammatory infiltrate. In multivariate analysis, the patients with 
      FT/body surface area >19 mL/m(2) had an increased mortality rate, with a relative 
      risk of 10.8. CONCLUSIONS: Our study provides evidence that LGE-CMR is useful in 
      the diagnosis and prognosis of EMF through quantification of the typical pattern 
      of FT deposition.
FAU - Salemi, Vera M C
AU  - Salemi VM
AD  - Cardiomyopathy Unit, Heart Institute (InCor) da Faculdade de Medicina da 
      Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Rochitte, Carlos E
AU  - Rochitte CE
FAU - Shiozaki, Afonso A
AU  - Shiozaki AA
FAU - Andrade, Joalbo M
AU  - Andrade JM
FAU - Parga, Jose R
AU  - Parga JR
FAU - de Avila, Luiz F
AU  - de Avila LF
FAU - Benvenuti, Luiz A
AU  - Benvenuti LA
FAU - Cestari, Ismar N
AU  - Cestari IN
FAU - Picard, Michael H
AU  - Picard MH
FAU - Kim, Raymond J
AU  - Kim RJ
FAU - Mady, Charles
AU  - Mady C
LA  - eng
PT  - Journal Article
DEP - 20110317
PL  - United States
TA  - Circ Cardiovasc Imaging
JT  - Circulation. Cardiovascular imaging
JID - 101479935
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Contrast Media
MH  - Endomyocardial Fibrosis/complications/*diagnosis/pathology/physiopathology
MH  - Female
MH  - *Gadolinium DTPA
MH  - Heart Failure/complications
MH  - Heart Ventricles/pathology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Stroke Volume
EDAT- 2011/03/19 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/03/19 06:00
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - CIRCIMAGING.110.950675 [pii]
AID - 10.1161/CIRCIMAGING.110.950675 [doi]
PST - ppublish
SO  - Circ Cardiovasc Imaging. 2011 May;4(3):304-11. doi: 
      10.1161/CIRCIMAGING.110.950675. Epub 2011 Mar 17.