PMID- 21416113
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20211020
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 27
IP  - 2
DP  - 2012 Mar
TI  - Platelet and monocyte activity markers and mediators of inflammation in Takotsubo 
      cardiomyopathy.
PG  - 186-92
LID - 10.1007/s00380-011-0132-6 [doi]
AB  - Patients with Takotsubo cardiomyopathy (TC) often present with symptoms similar 
      to those of myocardial infarction (MI). We analyzed blood concentrations of 
      mediators of inflammation and platelet- and monocyte-activity markers in patients 
      with TC and MI for significant differences. Clinical data of patients with TC (n 
      = 16) and acute MI (n = 16) were obtained. Serial blood samples were taken at the 
      time of hospital admission (t(0)), after 2-4 days (t(1)) and after 4-7 weeks 
      (t(2)), respectively. Plasma concentrations of interleukin (IL)-6, IL-7, soluble 
      CD40 ligand (sCD40L), and monocyte chemotactic protein 1 (MCP-1) were determined 
      with an ELISA. Tissue factor binding on monocytes, platelet-activation marker 
      CD62P, platelet CD40-ligand (CD40L), and platelet-monocyte aggregates were 
      measured using flow cytometry. Expression of CD62P on platelets and IL-6 plasma 
      levels were significantly lower in patients with TC compared to MI at the time of 
      hospital admission. IL-7 plasma levels were significantly elevated in patients 
      with TC compared to patients with MI at 2-4 days after hospital admission. No 
      significant differences were observed concerning sCD40L and MCP-1 plasma levels, 
      tissue factor binding on monocytes, CD40L expression on platelets, and 
      platelet-monocyte aggregates at any point in time. Our results indicate that 
      inflammatory mediators and platelet-activity markers contribute to the 
      differences in the pathogenesis of MI and TC.
FAU - Pirzer, Rainer
AU  - Pirzer R
AD  - 1st Department of Medicine (Cardiology), University Medical Centre Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 
      68167 Mannheim, Germany.
FAU - Elmas, Elif
AU  - Elmas E
FAU - Haghi, Dariusch
AU  - Haghi D
FAU - Lippert, Christiane
AU  - Lippert C
FAU - Kralev, Stefan
AU  - Kralev S
FAU - Lang, Siegfried
AU  - Lang S
FAU - Borggrefe, Martin
AU  - Borggrefe M
FAU - Kalsch, Thorsten
AU  - Kalsch T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110318
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Platelets/*immunology
MH  - Chi-Square Distribution
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Flow Cytometry
MH  - Germany
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*immunology
MH  - Myocardial Infarction/blood/*immunology
MH  - Patient Admission
MH  - *Platelet Activation
MH  - Prospective Studies
MH  - Takotsubo Cardiomyopathy/blood/*immunology
MH  - Thrombosis/blood/*immunology
MH  - Time Factors
EDAT- 2011/03/19 06:00
MHDA- 2012/07/17 06:00
CRDT- 2011/03/19 06:00
PHST- 2010/11/14 00:00 [received]
PHST- 2011/02/25 00:00 [accepted]
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - 10.1007/s00380-011-0132-6 [doi]
PST - ppublish
SO  - Heart Vessels. 2012 Mar;27(2):186-92. doi: 10.1007/s00380-011-0132-6. Epub 2011 
      Mar 18.