PMID- 21416238
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20221207
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 16
IP  - 2
DP  - 2012 Apr
TI  - Non-surgical periodontal therapy with and without subgingival minocycline 
      administration in patients with poorly controlled type II diabetes: a randomized 
      controlled clinical trial.
PG  - 599-609
LID - 10.1007/s00784-011-0535-x [doi]
AB  - The aim of this study was to evaluate changes in clinical parameters and levels 
      of inflammatory biomarkers in plasma in periodontal patients with poorly 
      controlled type 2 diabetes mellitus (T2DM) after non-surgical periodontal 
      therapy. Twenty-eight poorly controlled T2DM patients were randomly assigned to 
      treatment with scaling and root planning (SRP) and SRP + subgingival minocycline 
      administration. Clinical parameters, including the probing depth (PD), bleeding 
      on probing (BOP), plaque score (PS), clinical attachment level (CAL), and plasma 
      interleukin (IL)-6, soluble receptor of advanced glycation end products (sRAGE), 
      chronic reactive protein (CRP), and hemoglobin A1c (HbA1c) were measured before 
      and after a 6-month treatment period. Significant changes in PD, BOP, PS, and CAL 
      were found in both groups. The latent growth curve model showed an overall 
      reduction in the log HbA1c level in the SRP group (-0.082, p = 0.033). Small 
      changes in the log sRAGE level and log CRP level in plasma were found in both 
      groups. IL-6 in the plasma increased in the SRP group, but slightly decreased in 
      the SRP+minocycline group (0.469 pg/ml, p = 0.172). Non-surgical periodontal 
      therapy with or without subgingival minocycline application may achieve 
      significant periodontal improvement and moderate improvement in HbA1c, but had no 
      significant effect on plasma levels of IL-6, CRP, or sRAGE in patients with 
      poorly controlled T2DM. For patients with both periodontal diseases and diabetes, 
      non-surgical periodontal treatments may be helpful in their diabetic control.
FAU - Lin, Shih-Jung
AU  - Lin SJ
AD  - Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
FAU - Tu, Yu-Kang
AU  - Tu YK
FAU - Tsai, Shiow-Chwen
AU  - Tsai SC
FAU - Lai, Shih-Ming
AU  - Lai SM
FAU - Lu, Hsein-Kun
AU  - Lu HK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110318
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - FYY3R43WGO (Minocycline)
MH  - Administration, Topical
MH  - Adult
MH  - Aged
MH  - Anti-Bacterial Agents/administration & dosage/*therapeutic use
MH  - C-Reactive Protein/analysis
MH  - Dental Plaque Index
MH  - Dental Scaling/methods
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Gingival Hemorrhage/drug therapy/therapy
MH  - Glycated Hemoglobin/analysis
MH  - Glycation End Products, Advanced/blood
MH  - Humans
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Minocycline/administration & dosage/*therapeutic use
MH  - Periodontal Attachment Loss/drug therapy/therapy
MH  - Periodontal Diseases/drug therapy/*therapy
MH  - Periodontal Pocket/drug therapy/therapy
MH  - Receptor for Advanced Glycation End Products
MH  - Receptors, Immunologic/blood
MH  - Root Planing/methods
EDAT- 2011/03/19 06:00
MHDA- 2012/09/26 06:00
CRDT- 2011/03/19 06:00
PHST- 2010/08/18 00:00 [received]
PHST- 2011/02/22 00:00 [accepted]
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
AID - 10.1007/s00784-011-0535-x [doi]
PST - ppublish
SO  - Clin Oral Investig. 2012 Apr;16(2):599-609. doi: 10.1007/s00784-011-0535-x. Epub 
      2011 Mar 18.