PMID- 21417554
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20110419
IS  - 1440-1614 (Electronic)
IS  - 0004-8674 (Linking)
VI  - 45
IP  - 5
DP  - 2011 May
TI  - Clinical and cognitive correlates of psychiatric comorbidity in delusional 
      disorder outpatients.
PG  - 416-25
LID - 10.3109/00048674.2010.551279 [doi]
AB  - OBJECTIVES: The aims of this study were to investigate the prevalence, as well as 
      the clinical, cognitive, and functional correlates of psychiatric comorbidity in 
      patients with delusional disorder (DD). METHODS: Eighty-six outpatients with 
      DSM-IV DD were evaluated for psychiatric comorbidity on Axis I disorders using 
      the Mini International Neuropsychiatry Interview (MINI). The following 
      instruments were administered: the Standardized Assessment of Personality (SAP), 
      the Positive and Negative Symptom Scale (PANSS), the Montgomery-Asberg Depression 
      Rating Scale (MADRS), a neuropsychological battery (consisting of measures for 
      attention, verbal and working memory, and executive functions), the Sheehan 
      Disability Inventory (SDI), and the Global Assessment of Functioning (GAF) scale. 
      A socio-demographic and clinical questionnaire was also completed. RESULTS: 
      Forty-six percent of the subjects had at least one additional lifetime 
      psychiatric diagnosis, the most common being depressive disorders (N = 16, 
      32.6%), followed by anxiety disorders (N = 8, 14%). DD with comorbid Axis I 
      disorders (N = 40, 46.5%) was associated with a specific syndromic constellation 
      (more common cluster C personality psychopathology, somatic delusions, olfactory 
      and gustatory hallucinations, and suicide risk), and greater severity of the 
      psychopathology, particularly as regards emotional dysregulation (total and 
      general PANSS scales, MADRS, and perceived stress SDI scoring). In contrast, DD 
      without psychiatric comorbidity - "pure" DD - (N = 46, 53.5%) was associated with 
      worse overall neurocognitive performance, mainly in working memory. There were no 
      differences in functionality between the two groups (as per the GAF and SDI 
      total, work, social and family life disability scores). CONCLUSIONS: Our findings 
      reveal one type of DD with associated psychiatric comorbidity with greater 
      emotion-related psychopathology and another "pure" DD, without psychiatric 
      comorbidity, related to worse global cognitive functioning. Treatment for DD 
      should address both types of processes.
FAU - de Portugal, Enrique
AU  - de Portugal E
AD  - Department of Psychiatry, Hospital Gregorio Maranon, Madrid.
FAU - Martinez, Covadonga
AU  - Martinez C
FAU - Gonzalez, Nieves
AU  - Gonzalez N
FAU - del Amo, Victoria
AU  - del Amo V
FAU - Haro, Josep M
AU  - Haro JM
FAU - Cervilla, Jorge A
AU  - Cervilla JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110321
PL  - England
TA  - Aust N Z J Psychiatry
JT  - The Australian and New Zealand journal of psychiatry
JID - 0111052
SB  - IM
MH  - *Cognition
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Disorders/*epidemiology
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Outpatients
MH  - Personality Assessment
MH  - Prevalence
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia, Paranoid/*epidemiology/*psychology
MH  - Severity of Illness Index
MH  - Stress, Psychological/epidemiology
EDAT- 2011/03/23 06:00
MHDA- 2011/08/25 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
AID - 10.3109/00048674.2010.551279 [doi]
PST - ppublish
SO  - Aust N Z J Psychiatry. 2011 May;45(5):416-25. doi: 10.3109/00048674.2010.551279. 
      Epub 2011 Mar 21.