PMID- 21418168
OWN - NLM
STAT- MEDLINE
DCOM- 20110513
LR  - 20110322
IS  - 1751-0813 (Electronic)
IS  - 0005-0423 (Linking)
VI  - 89
IP  - 4
DP  - 2011 Apr
TI  - Porcine circovirus-associated disease in weaner pigs in Western Australia.
PG  - 122-30
LID - 10.1111/j.1751-0813.2010.00680.x [doi]
AB  - OBJECTIVE: To report the occurrence and pathology of porcine circovirus type 2 
      (PCV2)-associated disease (PCVAD) of postweaning pigs in two Australian pig 
      herds. METHODS: Mortality data from two commercial piggeries that experienced 
      higher than normal postweaning illthrift and mortalities were examined. Gross and 
      histopathological examinations were performed on the index cases, and at weekly 
      intervals thereafter for a period of 10 weeks. Specimens were submitted to the 
      laboratory for routine diagnostic testing and for exclusion of porcine 
      reproductive and respiratory syndrome virus (PRRSV). The genomes of two strains 
      of PCV2 isolated during testing were sequenced. RESULTS: Mortality rates in 
      weaned, 5-12-week-old pigs spiked significantly during mid to late 2007. This 
      increase in the mortalities was mainly attributed to salmonella-associated 
      diarrhoea and illthrift. Salmonellosis was diagnosed in 73/110 cases inclusive of 
      both piggeries. Many pigs also had chronic granulomatous lymphadenitis and 
      diffuse histiocytic interstitial pneumonia consistent with PCVAD and associated 
      with varying amounts of PCV2 antigen and inclusion bodies. All samples tested for 
      PRRSV were negative. Sequence analysis of the PCV2 isolates showed strain 
      differences between piggeries. CONCLUSION: This report describes the first 
      outbreaks of PCVAD in growing pigs in Western Australia (WA) and describes 
      lesions not previously seen in this laboratory. It also describes the first 
      isolation of a PCV2 group 1 virus in WA associated with PCVAD. Although the 
      outbreaks of PCVAD occurred with concurrent salmonellosis, the two diseases were 
      unrelated. Neither of the outbreaks met the Australian case definition for the 
      diagnosis of postweaning multisystemic wasting syndrome.
CI  - (c) 2011 Western Australian Agriculture Authority. Australian Veterinary Journal (c) 
      2011 Australian Veterinary Association.
FAU - O'Dea, M A
AU  - O'Dea MA
AD  - Animal Health Laboratories, Department of Agriculture and Food Western Australia, 
      South Perth, Australia. mark.odea@agric.wa.gov.au
FAU - Kabay, M J
AU  - Kabay MJ
FAU - Carr, J
AU  - Carr J
FAU - Wilcox, G E
AU  - Wilcox GE
FAU - Richards, R B
AU  - Richards RB
LA  - eng
PT  - Journal Article
PL  - England
TA  - Aust Vet J
JT  - Australian veterinary journal
JID - 0370616
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Circoviridae Infections/epidemiology/*veterinary
MH  - Circovirus/*isolation & purification
MH  - Comorbidity
MH  - Disease Outbreaks/veterinary
MH  - Female
MH  - Male
MH  - Salmonella Infections, Animal/*epidemiology
MH  - Swine
MH  - Swine Diseases/*epidemiology
MH  - Weaning
MH  - Western Australia/epidemiology
EDAT- 2011/03/23 06:00
MHDA- 2011/05/14 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/05/14 06:00 [medline]
AID - 10.1111/j.1751-0813.2010.00680.x [doi]
PST - ppublish
SO  - Aust Vet J. 2011 Apr;89(4):122-30. doi: 10.1111/j.1751-0813.2010.00680.x.