PMID- 21418266
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20171116
IS  - 1365-2990 (Electronic)
IS  - 0305-1846 (Linking)
VI  - 37
IP  - 7
DP  - 2011 Dec
TI  - The expression of CD36 in vessels with blood-brain barrier impairment in a 
      stroke-prone hypertensive model.
PG  - 727-37
LID - 10.1111/j.1365-2990.2011.01172.x [doi]
AB  - AIMS: The class B scavenger receptor CD36, the receptor for oxidized low-density 
      lipoprotein, mediates free radical production and brain injury in cerebral 
      ischaemia. Free radical production is known to be involved in the remodelling of 
      the cerebral vasculature of stroke-prone spontaneously hypertensive rats (SHRSP). 
      Accordingly, we examined whether the expression of CD36 is increased in the 
      vasculature with blood-brain barrier (BBB) impairment and collagen deposition of 
      SHRSP. METHODS: The gene and protein expression of CD36 was examined in the 
      vessels of the hippocampus of SHRSP with BBB impairment and those of Wistar Kyoto 
      rats without the impairment, by real-time RT-PCR, Western blotting and 
      immunohistochemical techniques. RESULTS: The gene and protein expression of CD36 
      was increased in the hippocampus of SHRSP compared with that of Wistar Kyoto 
      rats. Confocal microscopic examination revealed CD36 immunoreactivity in 
      perivascular microglial cells immunopositive for ED1. Immunoelectron microscopic 
      examination revealed that the immunosignals for CD36 were located mainly in the 
      cytoplasm of perivascular cells in vessels showing increased vascular 
      permeability and a few in the cytoplasmic membranes of endothelial cells. 
      CONCLUSIONS: These findings indicate that the expression of CD36 was increased in 
      vessels with BBB impairment in the hippocampus of SHRSP and was mainly seen in 
      the cytoplasm of perivascular microglial cells, suggesting a role of CD36 in 
      cerebrovascular injury.
CI  - (c) 2011 The Authors. Neuropathology and Applied Neurobiology (c) 2011 British 
      Neuropathological Society.
FAU - Ueno, M
AU  - Ueno M
AD  - Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 
      Kagawa, Japan. masaueno@med.kagawa-u.ac.jp
FAU - Nakagawa, T
AU  - Nakagawa T
FAU - Nagai, Y
AU  - Nagai Y
FAU - Nishi, N
AU  - Nishi N
FAU - Kusaka, T
AU  - Kusaka T
FAU - Kanenishi, K
AU  - Kanenishi K
FAU - Onodera, M
AU  - Onodera M
FAU - Hosomi, N
AU  - Hosomi N
FAU - Huang, C
AU  - Huang C
FAU - Yokomise, H
AU  - Yokomise H
FAU - Tomimoto, H
AU  - Tomimoto H
FAU - Sakamoto, H
AU  - Sakamoto H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropathol Appl Neurobiol
JT  - Neuropathology and applied neurobiology
JID - 7609829
RN  - 0 (CD36 Antigens)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*metabolism/physiopathology
MH  - CD36 Antigens/*metabolism
MH  - Endothelial Cells/metabolism
MH  - Endothelium, Vascular/*metabolism/physiopathology
MH  - Hippocampus/*blood supply/metabolism/physiopathology
MH  - Hypertension/*metabolism/physiopathology
MH  - Male
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Stroke/*metabolism/physiopathology
EDAT- 2011/03/23 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - 10.1111/j.1365-2990.2011.01172.x [doi]
PST - ppublish
SO  - Neuropathol Appl Neurobiol. 2011 Dec;37(7):727-37. doi: 
      10.1111/j.1365-2990.2011.01172.x.