PMID- 21418620
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20220331
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 9
DP  - 2011 Mar 21
TI  - Increase of plasma IL-9 and decrease of plasma IL-5, IL-7, and IFN-gamma in patients 
      with chronic heart failure.
PG  - 28
LID - 10.1186/1479-5876-9-28 [doi]
AB  - BACKGROUND: Several cytokines are associated with the development and/or 
      progression of chronic heart failure (CHF). Our aim was to look more closely at 
      the cytokine networks involved in CHF, and to assess whether disease etiology 
      affects cytokine expression. The study population was comprised of a) 69 patients 
      with stable CHF, New York Heart Association (NYHA) II/IV classes, secondary to 
      ischaemic (ICM) and non ischaemic dilated (NIDCM) cardiomyopathy and b) 16 
      control subjects. We analyzed and compared the plasma levels of 27 pro- and 
      anti-inflammatory mediators, in the study population and assessed for any 
      possible correlation with echocardiographic parameters and disease duration. 
      METHODS: 27 cytokines and growth factors were analyzed in the plasma of ICM- (n = 
      42) and NIDCM (n = 27) NYHA class II-IV patients vs age- and gender-matched 
      controls (n = 16) by a beadbased multiplex immunoassay. Statistical analysis was 
      performed by ANOVA followed by Tukey post-hoc test for multiple comparison. 
      RESULTS: Macrophage inflammatory protein (MIP)-1beta, Vascular endothelial growth 
      factor (VEGF), interleukin (IL)-9, Monocyte chemotactic protein (MCP)-1, and IL-8 
      plasma levels were increased in both ICM and NIDCM groups vs controls. In 
      contrast, IL-7, IL-5, and Interferon (IFN)-gamma were decreased in both ICM and NIDCM 
      groups as compared to controls. Plasma IL-6 and IL-1 beta were increased in ICM and 
      decreased in NIDCM, vs controls, respectively.IL-9 levels inversely correlated, 
      in ICM patients, with left ventricular ejection fraction (LVEF) while IL-5 plasma 
      levels inversely correlated with disease duration, in NYHA III/IV ICM 
      patients.This is the first time that both an increase of plasma IL-9, and a 
      decrease of plasma IL-5, IL-7 and IFN-gamma have been reported in ICM as well as in 
      NIDCM groups, vs controls. Interestingly, such cytokines are part of a network of 
      genes whose expression levels change during chronic heart failure. The altered 
      expression levels of MIP-1 beta, VEGF, MCP-1, IL-1 beta, IL-6, and IL-8, found in this 
      study, are in keeping with previous reports. CONCLUSIONS: The increase of plasma 
      IL-9, and the decrease of plasma IL-5, IL-7 and IFN-gamma in ICM as well as in NIDCM 
      groups vs controls may contribute to get further insights into the inflammatory 
      pathways involved in CHF.
FAU - Cappuzzello, Claudia
AU  - Cappuzzello C
AD  - Istituto Dermopatico dell'Immacolata-IRCCS, Rome, Italy.
FAU - Di Vito, Luca
AU  - Di Vito L
FAU - Melchionna, Roberta
AU  - Melchionna R
FAU - Melillo, Guido
AU  - Melillo G
FAU - Silvestri, Lorena
AU  - Silvestri L
FAU - Cesareo, Eleonora
AU  - Cesareo E
FAU - Crea, Filippo
AU  - Crea F
FAU - Liuzzo, Giovanna
AU  - Liuzzo G
FAU - Facchiano, Antonio
AU  - Facchiano A
FAU - Capogrossi, Maurizio C
AU  - Capogrossi MC
FAU - Napolitano, Monica
AU  - Napolitano M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110321
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-5)
RN  - 0 (Interleukin-7)
RN  - 0 (Interleukin-9)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiomyopathy, Dilated/blood/complications/diagnostic imaging/physiopathology
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Cytokines/*blood
MH  - Female
MH  - Gene Regulatory Networks/genetics
MH  - Heart Failure/*blood/complications/diagnostic imaging/physiopathology
MH  - Humans
MH  - Interferon-gamma/blood
MH  - Interleukin-5/blood
MH  - Interleukin-7/blood
MH  - Interleukin-9/blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/blood/complications/diagnostic imaging/physiopathology
MH  - Stroke Volume/physiology
MH  - Ultrasonography
PMC - PMC3068954
EDAT- 2011/03/23 06:00
MHDA- 2011/07/28 06:00
PMCR- 2011/03/21
CRDT- 2011/03/23 06:00
PHST- 2010/12/06 00:00 [received]
PHST- 2011/03/21 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
PHST- 2011/03/21 00:00 [pmc-release]
AID - 1479-5876-9-28 [pii]
AID - 10.1186/1479-5876-9-28 [doi]
PST - epublish
SO  - J Transl Med. 2011 Mar 21;9:28. doi: 10.1186/1479-5876-9-28.