PMID- 21418865
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20220408
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 4
DP  - 2011 Jan 25
TI  - [Association between side effects of oral anti-diabetic drugs and self-reported 
      mental health and quality of life among patients with type 2 diabetes].
PG  - 229-33
AB  - OBJECTIVE: To examine the association between the side effects of oral 
      anti-diabetic drugs (OAD) and self-reported mental health and quality of life 
      among patients with type 2 diabetes mellitus (T2DM). METHODS: An observational, 
      cross-sectional multicenter study with a retrospective medical chart review was 
      conducted at 16 medical centers from around China. The T2DM patients were 
      followed-up and treated with OAD alone prior to the index visit from January to 
      September 2007. All subjects were >/=30 years old at the time of T2DM diagnosis and 
      had received monotherapy or combination therapy of OAD for at least 6 months. 
      Health-related quality of life was measured by the EuroQol-5D (EQ-5D) and 
      Hypoglycemia Fear Survey (HFS)-II. RESULTS: The symptoms of hypoglycemia were 
      reported by 41.8% (n=203) of participants, and 19.2% (n=93) experienced weight 
      gain. For those reporting hypoglycemia, the scores were higher for HFS-II [7.00 
      (2.00-19.00) vs 0.00 (0.00-7.00), P<0.01] and lower for EQ-5D (0.90+/-0.12 vs 
      0.93+/-0.13, P=0.003) than those without hypoglycemic symptoms. According to the 
      multivariate linear regression analysis, the symptoms of hypoglycemia were 
      positively correlated with HFS-II (beta=5.78, P<0.01) and negatively with EQ-5D 
      (beta=-0.04, P<0.05) after adjusting for patient and disease characteristics. 
      CONCLUSION: There is a high possibility of hypoglycemic risks among T2DM patients 
      on OAD therapy. The self-reported hypoglycemia is associated with health-related 
      quality of life and hypoglycemic fear. They may have an impact on the long-term 
      prognosis.
FAU - Chen, Zong-cun
AU  - Chen ZC
AD  - Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China.
FAU - Zhang, Shao-ling
AU  - Zhang SL
FAU - Yan, Li
AU  - Yan L
FAU - Wu, Mu-chao
AU  - Wu MC
FAU - Chen, Li-hong
AU  - Chen LH
FAU - Ji, Li-nong
AU  - Ji LN
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Aged
MH  - Attitude to Health
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/drug therapy/*psychology
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/*adverse effects/therapeutic use
MH  - *Mental Health
MH  - Middle Aged
MH  - *Quality of Life
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
EDAT- 2011/03/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Jan 25;91(4):229-33.