PMID- 21419233 OWN - NLM STAT- MEDLINE DCOM- 20111028 LR - 20211020 IS - 1095-9564 (Electronic) IS - 1074-7427 (Print) IS - 1074-7427 (Linking) VI - 96 IP - 1 DP - 2011 Jul TI - Epigenetic gene regulation in the adult mammalian brain: multiple roles in memory formation. PG - 68-78 LID - 10.1016/j.nlm.2011.03.001 [doi] AB - Brain-derived neurotrophic factor (bdnf) is one of numerous gene products necessary for long-term memory formation and dysregulation of bdnf has been implicated in the pathogenesis of cognitive and mental disorders. Recent work indicates that epigenetic-regulatory mechanisms including the markings of histone proteins and associated DNA remain labile throughout the life-span and represent an attractive molecular process contributing to gene regulation in the brain. In this review, important information will be discussed on epigenetics as a set of newly identified dynamic transcriptional mechanisms serving to regulate gene expression changes in the adult brain with particular emphasis on bdnf transcriptional readout in learning and memory formation. This review will also highlight evidence for the role of epigenetics in aberrant bdnf gene regulation in the pathogenesis of cognitive dysfunction associated with seizure disorders, Rett syndrome, Schizophrenia, and Alzheimer's disease. Such research offers novel concepts for understanding epigenetic transcriptional mechanisms subserving adult cognition and mental health, and furthermore promises novel avenues for therapeutic approach in the clinic. CI - Copyright (c) 2011 Elsevier Inc. All rights reserved. FAU - Lubin, Farah D AU - Lubin FD AD - The Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, United States. flubin@nrc.uab.edu LA - eng GR - R00 MH082106-04/MH/NIMH NIH HHS/United States GR - K99 MH082106-01/MH/NIMH NIH HHS/United States GR - R00 MH082106-03/MH/NIMH NIH HHS/United States GR - K99 MH082106/MH/NIMH NIH HHS/United States GR - R00 MH082106-02/MH/NIMH NIH HHS/United States GR - FDL MH082106/MH/NIMH NIH HHS/United States GR - R01 MH097909/MH/NIMH NIH HHS/United States GR - R00 MH082106/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20110316 PL - United States TA - Neurobiol Learn Mem JT - Neurobiology of learning and memory JID - 9508166 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Histones) SB - IM MH - Animals MH - Brain/*metabolism MH - Brain-Derived Neurotrophic Factor/*genetics/metabolism MH - DNA Methylation MH - *Epigenesis, Genetic MH - *Gene Expression Regulation MH - Histones/genetics/metabolism MH - Memory/*physiology MH - Promoter Regions, Genetic PMC - PMC3111751 MID - NIHMS282614 EDAT- 2011/03/23 06:00 MHDA- 2011/10/29 06:00 PMCR- 2012/07/01 CRDT- 2011/03/23 06:00 PHST- 2010/11/01 00:00 [received] PHST- 2011/02/25 00:00 [revised] PHST- 2011/03/04 00:00 [accepted] PHST- 2011/03/23 06:00 [entrez] PHST- 2011/03/23 06:00 [pubmed] PHST- 2011/10/29 06:00 [medline] PHST- 2012/07/01 00:00 [pmc-release] AID - S1074-7427(11)00053-0 [pii] AID - 10.1016/j.nlm.2011.03.001 [doi] PST - ppublish SO - Neurobiol Learn Mem. 2011 Jul;96(1):68-78. doi: 10.1016/j.nlm.2011.03.001. Epub 2011 Mar 16.