PMID- 21419267
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20131121
IS  - 0083-6729 (Print)
IS  - 0083-6729 (Linking)
VI  - 86
DP  - 2011
TI  - Dendritic cells modified by vitamin D: future immunotherapy for autoimmune 
      diseases.
PG  - 63-82
LID - 10.1016/B978-0-12-386960-9.00003-4 [doi]
AB  - Dendritic cells (DCs), the most potent antigen-presenting cells of the immune 
      system, express nuclear receptors for 1,25-dihydroxyvitamin D(3) (VD3) and they 
      are one of its main targets. In the presence of VD3, DCs differentiate into a 
      phenotype that resembles semimature DCs, with reduced T cell costimulatory 
      molecules and hampered IL-12 production. These VD3-modulated DCs induce T cell 
      tolerance in vitro using multiple mechanisms such as rendering T cells anergic, 
      dampening of Th1 responses, and recruiting and differentiating regulatory T 
      cells. Due to their ability to specifically target pathological T cells, 
      VD3-modulated DCs are safe and potentially more effective alternatives to 
      currently available immunoregulatory therapies. While a number of considerations 
      remain, including the establishment of a reliable quality control measure to 
      ensure the safety and efficacy of VD3-DCs in vivo and the optimal frequency, 
      dose, and route of DC administration to achieve therapeutic effects in humans, 
      adoptive VD3-DC transfer represents one of the most promising approaches to 
      future treatment of autoimmune diseases.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Pedersen, Ayako Wakatsuki
AU  - Pedersen AW
AD  - DanDrit Biotech A/S, Symbion Science Park, Copenhagen, Denmark.
FAU - Claesson, Mogens Helweg
AU  - Claesson MH
FAU - Zocca, Mai-Britt
AU  - Zocca MB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Vitam Horm
JT  - Vitamins and hormones
JID - 0413601
RN  - 1406-16-2 (Vitamin D)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/immunology/metabolism/*therapy
MH  - Calcitriol/metabolism/pharmacology
MH  - Dendritic Cells/*drug effects/immunology/metabolism/transplantation
MH  - Humans
MH  - *Immunotherapy
MH  - Vitamin D/metabolism/*pharmacology
EDAT- 2011/03/23 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - B978-0-12-386960-9.00003-4 [pii]
AID - 10.1016/B978-0-12-386960-9.00003-4 [doi]
PST - ppublish
SO  - Vitam Horm. 2011;86:63-82. doi: 10.1016/B978-0-12-386960-9.00003-4.