PMID- 21421503
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20131121
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 31
IP  - 3
DP  - 2011 Mar
TI  - [Association of elevated uric acid with metabolic disorders and analysis of the 
      risk factors of hyperuricemia in type 2 diabetes mellitus].
PG  - 544-7
AB  - OBJECTIVE: To explore the association of elevated serum uric acid with metabolic 
      disorders and the risk factors of hyperuricemia in type 2 diabetes mellitus 
      (T2DM). METHODS: The clinical and laboratory data of 159 T2DM patients aged 40-80 
      years with a Scr level of 51-159 micromol/L (0.6-1.8 mg/dl) were analyzed to explore 
      the association of hyperuricemia (HUA) with metabolic disorders and identify the 
      risk factors of HUA. RESULTS: Forty out of 159 T2DM patients (25.2%) were found 
      to have HUA. Univariate analysis showed that male gender, a body mass index </=25 
      kg/m(2), hypertension, serum creatinine </=110 micromol/L, blood urea nitrogen </=7.0 
      mmol/L, microalbuminuria :11.2 mg/L, triglyceride :1.70 mmol/L, high-density 
      lipoprotein <1.04 mmol/L, low density lipoprotein </=3.37 mmol/L were all risk 
      factors of HUA (P<0.05) in T2DM. Binary logistic regression analysis identified 
      serum creatinine, body mass index and triglyceride as independent risk factors of 
      HUA in T2DM. The main risk factors related to HUA had high incidences in T2DM. 
      Patients with HUA had a significantly higher incidences of coronary artery 
      disease, carotid atherosclerosis, cerebral infarction, diabetic nephropathy and 
      diabetic retinopathy than those with normal uric acid level (P<0.05). CONCLUSION: 
      Several risk factors contribute to the occurrence of elevated serum uric acid in 
      T2DM, and metabolic disorders and complications are also closely associated with 
      HUA.
FAU - WU, Dan
AU  - WU D
AD  - Department of Nephropathy, Zhujiang Hospital, Southern Medical University, 
      Guangzhou 510282, China. wudanjw@21cn.com
FAU - LIU, Hong
AU  - LIU H
FAU - LI, Shen-heng
AU  - LI SH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Female
MH  - Humans
MH  - Hyperuricemia/etiology/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Uric Acid/*blood
EDAT- 2011/03/23 06:00
MHDA- 2013/03/06 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2011 Mar;31(3):544-7.