PMID- 21422655
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20220318
IS  - 0975-4466 (Electronic)
IS  - 0256-4947 (Print)
IS  - 0256-4947 (Linking)
VI  - 31
IP  - 2
DP  - 2011 Mar-Apr
TI  - Frequency of HLA-DRB1 alleles in rheumatoid arthritis patients in Zahedan, 
      southeast Iran.
PG  - 171-3
LID - 10.4103/0256-4947.78205 [doi]
AB  - BACKGROUND AND OBJECTIVES: Analysis of the role of different alleles of human 
      leukocyte antigen (HLA) in rheumatoid arthritis (RA) patients is necessary in 
      many populations and geographical areas. The aim of the present study was to 
      investigate the frequency of HLA-DRB1 alleles in RA patients, comparing with that 
      in control group in southeast Iran. DESIGN AND SETTING: Case-control study of 
      rheumatoid arthritis patients referred to rheumatology clinic at university 
      hospital. PATIENTS AND METHODS: The frequency of HLA-DRB1 alleles was determined 
      in 79 RA patients and 93 healthy subjects in Zahedan, southeast Iran. HLA-DRB1 
      allele types were identified by polymerase chain reaction with sequence-specific 
      primer (PCR-SSP). RESULTS: The HLA-DRB1FNx0110 allele showed a significantly 
      higher frequency in patients with RA (OR=2.698, 95% CI=1.087-6.699, P=.045), 
      while the frequency of DRB1FNx0103 allele in these subjects was significantly 
      lower than that in the control group (OR=0.447, 95% CI=0.2285-0.8729, P=.021). 
      The frequencies of DRB1FNx0101, DRB1FNx0104, DRB1FNx0107, DRB1FNx0109, 
      DRB1FNx0111, DRB1FNx0113, DRB1FNx0114, DRB1FNx0115, DRB1FNx0116 were not 
      significantly different between RA subjects and the control group. CONCLUSION: 
      The data suggest that the DRB1FNx0110 allele is a risk factor and DRB1FNx0103 is 
      protective for RA in this population.
FAU - Sandoughi, Mahnaz
AU  - Sandoughi M
AD  - Department of Medical Parasitology, Medical School, Zahedan University of Medical 
      Sciences, Zahedan, Iran.
FAU - Fazaeli, Asghar
AU  - Fazaeli A
FAU - Bardestani, Gholamreza
AU  - Bardestani G
FAU - Hashemi, Mohammad
AU  - Hashemi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Saudi Arabia
TA  - Ann Saudi Med
JT  - Annals of Saudi medicine
JID - 8507355
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Arthritis, Rheumatoid/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Polymerase Chain Reaction
MH  - Risk Factors
MH  - Young Adult
PMC - PMC3102478
EDAT- 2011/03/23 06:00
MHDA- 2011/07/19 06:00
PMCR- 2011/03/01
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - AnnSaudiMed_2011_31_2_171_78205 [pii]
AID - ASM-31-171 [pii]
AID - 10.4103/0256-4947.78205 [doi]
PST - ppublish
SO  - Ann Saudi Med. 2011 Mar-Apr;31(2):171-3. doi: 10.4103/0256-4947.78205.