PMID- 21423411
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 2
DP  - 2011
TI  - Increased Cell-Cell Coupling Increases Infarct Size and Does not Decrease 
      Incidence of Ventricular Tachycardia in Mice.
PG  - 1
LID - 10.3389/fphys.2011.00001 [doi]
LID - 1
AB  - Increasing connexin43 (Cx43) gap junctional conductance as a means to improve 
      cardiac conduction has been proposed as a novel antiarrhythmic modality. Yet, 
      transmission of molecules via gap junctions may be associated with increased 
      infarct size. To determine whether maintaining open gap junction channels impacts 
      on infarct size and induction of ventricular tachycardia (VT) following coronary 
      occlusion, we expressed the pH- and voltage-independent connexin isoform 
      connexin32 (Cx32) in ventricle and confirmed Cx32 expression. Wild-type (WT) mice 
      injected with adenovirus-Cx32 (Cx32inj) were examined following coronary 
      occlusion to determine infarct size and inducibility of VT. There was an 
      increased infarct size in Cx32inj hearts as compared to WT (WT 22.9 +/- 4%; Cx32inj 
      44.3 +/- 5%; p < 0.05). Programmed electrical stimulation showed no difference in 
      VT inducibility in WT and Cx32inj mice (VT was reproducibly inducible in 55% of 
      shams and 50% of Cx32inj mice (p > 0.05). Following coronary occlusion, improving 
      cell-cell communication increased infarct size, and conferred no antiarrhythmic 
      benefit.
FAU - Prestia, Kevin A
AU  - Prestia KA
AD  - Department of Pharmacology, College of Physicians and Surgeons, Columbia 
      University New York, NY, USA.
FAU - Sosunov, Eugene A
AU  - Sosunov EA
FAU - Anyukhovsky, Evgeny P
AU  - Anyukhovsky EP
FAU - Dolmatova, Elena
AU  - Dolmatova E
FAU - Kelly, Caitlin W
AU  - Kelly CW
FAU - Brink, Peter R
AU  - Brink PR
FAU - Robinson, Richard B
AU  - Robinson RB
FAU - Rosen, Michael R
AU  - Rosen MR
FAU - Duffy, Heather S
AU  - Duffy HS
LA  - eng
GR  - R01 HL066140/HL/NHLBI NIH HHS/United States
GR  - R01 HL067101/HL/NHLBI NIH HHS/United States
GR  - R01 HL083205/HL/NHLBI NIH HHS/United States
GR  - R01 HL094410/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20110131
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC3059611
OTO - NOTNLM
OT  - antiarrhythmic therapy
OT  - connexin32
OT  - connexin43
OT  - coronary occlusion
OT  - infarct size
OT  - myocardial infarction
EDAT- 2011/03/23 06:00
MHDA- 2011/03/23 06:01
PMCR- 2011/01/31
CRDT- 2011/03/23 06:00
PHST- 2010/10/22 00:00 [received]
PHST- 2011/01/04 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/03/23 06:01 [medline]
PHST- 2011/01/31 00:00 [pmc-release]
AID - 10.3389/fphys.2011.00001 [doi]
PST - epublish
SO  - Front Physiol. 2011 Jan 31;2:1. doi: 10.3389/fphys.2011.00001. eCollection 2011.