PMID- 21424604
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20220311
IS  - 1573-0832 (Electronic)
IS  - 0301-486X (Linking)
VI  - 172
IP  - 2
DP  - 2011 Aug
TI  - Paracoccidioidomycosis in a dog: case report of generalized lymphadenomegaly.
PG  - 147-52
LID - 10.1007/s11046-011-9412-z [doi]
AB  - Paracoccidioidomycosis (PCM) is a severe systemic mycosis, endemic in Latin 
      America and highly prevalent in Brazil, where it ranks eighth as a mortality 
      cause among infectious and parasitic diseases in humans. The disease in animals 
      has been little explored. It is observed that armadillos can harbor the fungus at 
      high frequencies, although the active disease has not been well documented in 
      this wild mammal. Dogs are susceptible to experimental infection, and the 
      naturally acquired PCM-disease was reported only recently in a dog from Brazil. 
      The present work reports the second case of naturally acquired PCM in a 
      6-year-old female dog that presented emaciation, lymphadenomegaly, and 
      hepatosplenomegaly. Biochemical and pulmonary radiographic evaluation did not 
      reveal any abnormalities. PCM was diagnosed by clinical findings, culturing, 
      immunohistochemistry, and histopathology of popliteal lymph node. The fungus was 
      recovered from popliteal lymph node, and the molecular analysis showed respective 
      sequencing similarities of 99 and 100% for 803 nucleotides of the Gp43 gene and 
      592 nucleotides from the ITS-5.8S region of Paracoccidioides brasiliensis. 
      Immunohistochemistry revealed severe lymphadenitis and presented numerous yeasts, 
      which reacted against the gp43 antibody. Histopathology revealed a severe 
      granulomatous lymphadenitis associated with numerous single or multiple budding 
      yeasts. After diagnosis, the dog was successfully treated with itraconazol for 2 
      years. Veterinarians should be aware of the importance of considering PCM for 
      differential diagnosis, especially in dogs from PCM-endemic areas, whose 
      monophagocytic system involvement is evident.
FAU - de Farias, Marconi Rodrigues
AU  - de Farias MR
AD  - Department of Clinical Veterinary Medicine for Companion Animals, PUCPR, Sao Jose 
      dos Pinhais, PR, Brazil.
FAU - Condas, Larissa Anuska Zeni
AU  - Condas LA
FAU - Ribeiro, Marcio Garcia
AU  - Ribeiro MG
FAU - Bosco, Sandra de Moraes Gimenes
AU  - Bosco Sde M
FAU - Muro, Marisol Dominguez
AU  - Muro MD
FAU - Werner, Juliana
AU  - Werner J
FAU - Theodoro, Raquel Cordeiro
AU  - Theodoro RC
FAU - Bagagli, Eduardo
AU  - Bagagli E
FAU - Marques, Silvio Alencar
AU  - Marques SA
FAU - Franco, Marcello
AU  - Franco M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110320
PL  - Netherlands
TA  - Mycopathologia
JT  - Mycopathologia
JID - 7505689
RN  - 0 (Antifungal Agents)
RN  - 0 (DNA, Fungal)
RN  - 0 (DNA, Ribosomal)
RN  - 0 (DNA, Ribosomal Spacer)
RN  - 0 (Fungal Proteins)
RN  - 0 (RNA, Ribosomal, 5.8S)
RN  - 304NUG5GF4 (Itraconazole)
SB  - IM
MH  - Animals
MH  - Antifungal Agents/administration & dosage
MH  - Brazil
MH  - DNA, Fungal/chemistry/genetics
MH  - DNA, Ribosomal/chemistry/genetics
MH  - DNA, Ribosomal Spacer/chemistry/genetics
MH  - Dog Diseases/diagnosis/*drug therapy/*pathology
MH  - Dogs
MH  - Female
MH  - Fungal Proteins/genetics
MH  - Histocytochemistry
MH  - Immunohistochemistry
MH  - Itraconazole/administration & dosage
MH  - Lymph Nodes/pathology
MH  - Lymphatic Diseases/drug therapy/*microbiology/*pathology
MH  - Paracoccidioides/*isolation & purification
MH  - Paracoccidioidomycosis/diagnosis/drug therapy/pathology/*veterinary
MH  - RNA, Ribosomal, 5.8S/genetics
MH  - Sequence Analysis, DNA
MH  - Treatment Outcome
EDAT- 2011/03/23 06:00
MHDA- 2011/11/08 06:00
CRDT- 2011/03/23 06:00
PHST- 2010/07/30 00:00 [received]
PHST- 2011/03/06 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - 10.1007/s11046-011-9412-z [doi]
PST - ppublish
SO  - Mycopathologia. 2011 Aug;172(2):147-52. doi: 10.1007/s11046-011-9412-z. Epub 2011 
      Mar 20.