PMID- 21425481
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20110322
IS  - 0219-6352 (Print)
IS  - 0219-6352 (Linking)
VI  - 10
IP  - 1
DP  - 2011 Mar
TI  - The time course of visual backward masking deficits in schizophrenia.
PG  - 33-45
AB  - Schizophrenia, it has been hypothesized, is linked to a deficiency in the 
      magnocellular portion of the visual system. Abnormal backward masking has been 
      invoked as support for this hypothesis. The rationale for linking backward 
      masking to the magnocellular system is the hypothesis that fast responses in the 
      magnocellular systems catches up with, and then inhibits slower responses in the 
      parvocellular system. However, the latency difference between the magno- and 
      parvocellular systems is at most 20 ms. Magnocellular abnormalities as a result 
      would be expected to manifest themselves only at relatively short stimulus onset 
      asynchronies (SOAs) or interstimulus intervals (ISIs). The present study examines 
      this implication. It is found that a substantial number of investigations have 
      uncovered abnormal masking at SOAs or ISIs of 300 ms or larger, and some even at 
      ISIs as large as 700 ms. It is difficult to reconcile abnormalities at these SOAs 
      and ISIs with magno-parvocellular latency differences of 20 ms or less. It is 
      concluded that the abnormal masking does not support the existence of a 
      magnocellular deficiency in schizophrenia.
CI  - (c) Imperial College Press
FAU - Skottun, Bernt C
AU  - Skottun BC
AD  - Ullevalsalleen 4C, 0852 Oslo, Norway. berntskottun@yahoo.com
FAU - Skoyles, John R
AU  - Skoyles JR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - Singapore
TA  - J Integr Neurosci
JT  - Journal of integrative neuroscience
JID - 101156357
SB  - IM
MH  - Animals
MH  - Humans
MH  - Perceptual Masking/*physiology
MH  - Photic Stimulation/*methods
MH  - Reaction Time/*physiology
MH  - Schizophrenia/diagnosis/*physiopathology
MH  - *Schizophrenic Psychology
MH  - Visual Pathways/*physiology
EDAT- 2011/03/23 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/03/23 06:00
PHST- 2010/12/12 00:00 [received]
PHST- 2011/01/24 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - S0219635211002609 [pii]
AID - 10.1142/S0219635211002609 [doi]
PST - ppublish
SO  - J Integr Neurosci. 2011 Mar;10(1):33-45. doi: 10.1142/S0219635211002609.