PMID- 21426632
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20110323
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 13
IP  - 3
DP  - 2011 Mar
TI  - [Th1/Th2 immune response in bronchoalveolar lavage fluid in children with severe 
      Mycoplasma pneumoniae pneumonia].
PG  - 188-90
AB  - OBJECTIVE: To study the status of Th1/Th2 immune response and the value of the 
      detection of cytokines in bronchoalveolar lavage fluids (BALF) by examining the 
      levels of IFN-gamma and IL-4 in BALF and serum in children with severe Mycoplasma 
      pneumonia (MPP). METHODS: The levels of IFN-gamma and IL-4 in BALF and serum were 
      measured using ELISA in 25 children with severe MPP, 25 children with mild MPP 
      and 25 children with foreign body in bronchus. RESULTS: The levels of IL-4 and 
      IFN-gamma and the IL-4/IFN-gamma ratio in BALF in children with severe MPP were 
      significantly higher than those in children with foreign body in bronchus (P<0.01 
      or P<0.05). The serum levels of IL-4 and the IL-4/IFN-gamma ratio in children with 
      severe MPP were significantly higher than those in children with foreign body in 
      bronchus (P<0.01) or with mild MPP (P<0.05). The levels of IL-4 and the 
      IL-4/IFN-gamma ratio in BALF were significantly higher than in serum (P<0.05). 
      CONCLUSIONS: The data suggest that the imbalance of Th1/Th2 exists in children 
      with severe MPP and it seems to represent a predominant Th2-like cytokine 
      response. The detection of cytokines in BALF appears to be more sensitive than in 
      serum and may be of value in the diagnosis and therapy of MPP.
FAU - Kang, Yan-Meng
AU  - Kang YM
AD  - Department of Respiratory Medicine, Qilu Children's Hospital, Shandong 
      University, Jinan 250022, China.
FAU - Ding, Ming-Jie
AU  - Ding MJ
FAU - Han, Yu-Ling
AU  - Han YL
FAU - Wang, Shi-Fu
AU  - Wang SF
FAU - Ma, Xiang
AU  - Ma X
FAU - Li, Hua
AU  - Li H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Bronchoalveolar Lavage Fluid/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Interferon-gamma/blood
MH  - Interleukin-4/blood
MH  - Male
MH  - Pneumonia, Mycoplasma/*immunology
MH  - Th1 Cells/*immunology
MH  - Th2 Cells/*immunology
EDAT- 2011/03/24 06:00
MHDA- 2011/06/10 06:00
CRDT- 2011/03/24 06:00
PHST- 2011/03/24 06:00 [entrez]
PHST- 2011/03/24 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 1008-8830(2011)03-0188-03 [pii]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2011 Mar;13(3):188-90.