PMID- 21427221
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20211203
IS  - 1945-7170 (Electronic)
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 152
IP  - 5
DP  - 2011 May
TI  - Genetic ablation of sfrp4 in mice does not affect serum phosphate homeostasis.
PG  - 2031-6
LID - 10.1210/en.2010-1351 [doi]
AB  - Serum phosphate levels are regulated by PTH and the fibroblast growth factor 23 
      (Fgf23)/Klotho endocrine system, which both affect expression of Npt2a and thus 
      the apical reabsorption of phosphate in the proximal renal tubules. In addition 
      to Fgf23, secreted frizzled-related protein 4 (Sfrp4) has recently been 
      implicated as an additional phosphate regulator in vivo and in vitro. Here we 
      demonstrate that ablation of the Sfrp4 gene in mice does not lead to altered 
      serum or urine phosphate levels. Furthermore, Sfrp4 is unable to compensate for 
      the absence of Fgf23 or Klotho because double knockouts have a similar 
      biochemical profile and phenotype as animals with ablation of Fgf23 or Klotho 
      alone. Taken together, our data suggest that Sfrp4 does not contribute to the 
      long-term regulation of serum phosphate levels in mice.
FAU - Christov, Marta
AU  - Christov M
AD  - Department of Medicine, Harvard School of Dental Medicine, Boston, Massachusetts 
      02115, USA. mchrist3@bidmc.harvard.edu
FAU - Koren, Shany
AU  - Koren S
FAU - Yuan, Quan
AU  - Yuan Q
FAU - Baron, Roland
AU  - Baron R
FAU - Lanske, Beate
AU  - Lanske B
LA  - eng
GR  - T32 DK007199/DK/NIDDK NIH HHS/United States
GR  - DK073944/DK/NIDDK NIH HHS/United States
GR  - R01 DK073944/DK/NIDDK NIH HHS/United States
GR  - T32 DK007199-33/DK/NIDDK NIH HHS/United States
GR  - R56 DK073944/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110322
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Fgf23 protein, mouse)
RN  - 0 (Phosphates)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Sfrp4 protein, mouse)
RN  - 0 (Slc34a1 protein, mouse)
RN  - 0 (Sodium-Phosphate Cotransporter Proteins, Type IIa)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - 7Q7P4S7RRE (Fibroblast Growth Factor-23)
RN  - EC 3.2.1.31 (Glucuronidase)
RN  - EC 3.2.1.31 (Klotho Proteins)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Calcium/blood
MH  - Female
MH  - Fibroblast Growth Factor-23
MH  - Fibroblast Growth Factors/genetics/metabolism
MH  - Glucuronidase/genetics/metabolism
MH  - *Homeostasis
MH  - Klotho Proteins
MH  - Male
MH  - Mice
MH  - Mice, 129 Strain
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Phenotype
MH  - Phosphates/*blood/urine
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - Sodium-Phosphate Cotransporter Proteins, Type IIa/metabolism
MH  - Time Factors
PMC - PMC3075942
EDAT- 2011/03/24 06:00
MHDA- 2011/07/23 06:00
PMCR- 2012/05/01
CRDT- 2011/03/24 06:00
PHST- 2011/03/24 06:00 [entrez]
PHST- 2011/03/24 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - en.2010-1351 [pii]
AID - EN-10-1351 [pii]
AID - 10.1210/en.2010-1351 [doi]
PST - ppublish
SO  - Endocrinology. 2011 May;152(5):2031-6. doi: 10.1210/en.2010-1351. Epub 2011 Mar 
      22.