PMID- 21427654
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20151119
IS  - 1827-1839 (Electronic)
IS  - 0392-9590 (Linking)
VI  - 30
IP  - 2
DP  - 2011 Apr
TI  - Effects of buflomedil on skin blood flow in patients with type 2 diabetes 
      mellitus without overt micro- or macroangiopathy.
PG  - 164-71
AB  - AIM: The aim of this study was to assess the effects of buflomedil on the 
      peripheral microcirculation in patients with type 2 diabetes mellitus (T2DM) 
      without overt micro- or macroangiopathy. METHODS: Twenty-three patients with T2DM 
      were randomly assigned to receive buflomedil 600 mg/day for six months (N.=12) or 
      no medication (N.=11). Skin blood flow in the lower limbs was assessed at 
      baseline and after 3 and 6 months using Laser Doppler. We measured the following 
      laser Doppler parameters: volume, flow and velocity. RESULTS: In patients treated 
      with buflomedil, there was a significant increase in volume (P=0.039) and a trend 
      for an increase in both flow and velocity (P=0.097 for both parameters). In 
      contrast, significant decreases in volume and flow were observed in the control 
      group (P=0.045 and P=0.027, respectively) whereas velocity did not change 
      (P=0.150). CONCLUSION: In conclusion, buflomedil appears to have a beneficial 
      effect on the peripheral microcirculation in patients with T2DM.
FAU - Tsantilas, D
AU  - Tsantilas D
AD  - Department of Internal Medicine, Georgios Gennimatas General Hospital, 
      Thessaloniki, Greece.
FAU - Hatzitolios, A I
AU  - Hatzitolios AI
FAU - Tziomalos, K
AU  - Tziomalos K
FAU - Karamitsos, D
AU  - Karamitsos D
FAU - Papadimitriou, D
AU  - Papadimitriou D
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Italy
TA  - Int Angiol
JT  - International angiology : a journal of the International Union of Angiology
JID - 8402693
RN  - 0 (Biomarkers)
RN  - 0 (Pyrrolidines)
RN  - 0 (Vasodilator Agents)
RN  - V7I71DQ432 (buflomedil)
SB  - IM
MH  - Biomarkers/blood
MH  - Blood Flow Velocity/drug effects
MH  - Chi-Square Distribution
MH  - Diabetes Mellitus, Type 2/blood/complications/*drug therapy/physiopathology
MH  - Female
MH  - Foot Ulcer/etiology/physiopathology/prevention & control
MH  - Greece
MH  - Humans
MH  - Laser-Doppler Flowmetry
MH  - Lower Extremity
MH  - Male
MH  - Microcirculation/*drug effects
MH  - Middle Aged
MH  - Pyrrolidines/*therapeutic use
MH  - Regional Blood Flow/drug effects
MH  - Skin/*blood supply
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vasodilator Agents/*therapeutic use
EDAT- 2011/03/24 06:00
MHDA- 2011/07/26 06:00
CRDT- 2011/03/24 06:00
PHST- 2011/03/24 06:00 [entrez]
PHST- 2011/03/24 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
AID - R34112492 [pii]
PST - ppublish
SO  - Int Angiol. 2011 Apr;30(2):164-71.