PMID- 21428916
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20211203
IS  - 1470-8752 (Electronic)
IS  - 0300-5127 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Apr
TI  - Signalling by amino acid nutrients.
PG  - 443-5
LID - 10.1042/BST0390443 [doi]
AB  - It is clear that mTORC1 (mammalian target of rapamycin complex 1) is regulated by 
      the presence of ambient amino acid nutrients. However, the mechanism by which 
      amino acids regulate mTORC1 is still open to question, despite extensive efforts. 
      Our recent work has revealed that PR61ϵ, a B56 family regulatory subunit of PP2A 
      (protein phosphatase 2A), associates with and regulates the activity of MAP4K3 
      (mitogen-activated protein kinase kinase kinase kinase 3), a protein kinase 
      regulated by amino acid sufficiency that acts upstream of mTORC1. In searching 
      for a physiological process regulated by amino acids, we have demonstrated 
      recently that arginine plays a role in the activation of LPS 
      (lipopolysaccharide)-induced MEK [MAPK (mitogen-activated protein kinase)/ERK 
      (extracellular-signal-regulated kinase) kinase]/ERK signalling in macrophages. 
      PP2A similarly associates with the upstream regulator of MEK in this signalling 
      pathway, TPL-2 (tumour progression locus-2), in response to arginine 
      availability. Thus PP2A is a negative regulator of both MAP4K3 and TPL-2 in both 
      mTORC1 and MEK/ERK signalling pathways.
FAU - Yan, Lijun
AU  - Yan L
AD  - Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, 
      Alberta, Canada, T6G IZ2.
FAU - Lamb, Richard F
AU  - Lamb RF
LA  - eng
GR  - Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (Amino Acids)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.11.1 (MAP4K3 protein, human)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
RN  - EC 2.7.11.25 (MAP3K8 protein, human)
RN  - EC 3.1.3.16 (Protein Phosphatase 2)
SB  - IM
MH  - Amino Acids/metabolism/pharmacology/*physiology
MH  - Animals
MH  - *Food
MH  - Humans
MH  - MAP Kinase Kinase Kinases/genetics/metabolism/physiology
MH  - MAP Kinase Signaling System/drug effects/genetics/physiology
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Multiprotein Complexes
MH  - Protein Phosphatase 2/genetics/metabolism/physiology
MH  - Protein Serine-Threonine Kinases/genetics/metabolism/physiology
MH  - Proteins/genetics/metabolism/physiology
MH  - Proto-Oncogene Proteins/genetics/metabolism/physiology
MH  - Signal Transduction/drug effects/*physiology
MH  - TOR Serine-Threonine Kinases
EDAT- 2011/03/25 06:00
MHDA- 2011/07/02 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - BST0390443 [pii]
AID - 10.1042/BST0390443 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2011 Apr;39(2):443-5. doi: 10.1042/BST0390443.