PMID- 21429069
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20220408
IS  - 1708-8208 (Electronic)
IS  - 1523-0899 (Linking)
VI  - 14
IP  - 5
DP  - 2012 Oct
TI  - Tenascin-C and matrix metalloproteinase-9 levels in crevicular fluid of teeth and 
      implants.
PG  - 672-81
LID - 10.1111/j.1708-8208.2010.00319.x [doi]
AB  - BACKGROUND: The role of and interaction between bacterial infection and 
      biomechanical impact in the development of peri-implant inflammatory processes is 
      not clear. OBJECTIVE: To determine the amount and concentration of tenascin-C 
      (TNC) in gingival crevicular fluid (GCF) around teeth and in peri-implant sulcus 
      fluid from healthy implants and implants with peri-implantitis, and to correlate 
      it with matrix metalloproteinase-9 (MMP-9) levels. MATERIALS AND METHODS: Seven 
      control individuals and 18 patients with 41 implants with/without 
      peri-implantitis were included. GCF was collected with filter strips and volumes 
      were measured with a Periotron device. The amount of serum albumin per sample was 
      quantified by densitometric analysis of Coomassie-stained sodium dodecyl 
      sulfate-polyacrylamide gel electrophoresis. Relative activity of MMP-9 was 
      determined from the densitometry of zymograms. Amounts and concentrations of TNC 
      were evaluated by ELISA. RESULTS: Relative MMP-9 activity was increased in 
      peri-implantitis. A tendency was observed to measure higher TNC concentrations at 
      teeth than at implants. The amount of TNC in GCF collected from healthy implant 
      sites and the peri-implantitis sites was significantly different. Based on 
      immunoblotting, TNC in GCF seemed degraded. In contrast to TNC, MMP-9 was 
      significantly related to the PD and the volume of GCF. CONCLUSION: TNC is known 
      to be induced in inflammation. The increase found in peri-implantitis was less 
      than expected. In the context of peri-implantitis, TNC might be a marker of bone 
      remodelling rather than inflammation and infection. A possible proteolytic 
      degradation of TNC during peri-implantitis needs to be studied.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Ozcakir-Tomruk, Ceyda
AU  - Ozcakir-Tomruk C
AD  - Department of Prosthodontics, School of Dentistry, University of Bern, Bern, 
      Switzerland.
FAU - Chiquet, Matthias
AU  - Chiquet M
FAU - Mericske-Stern, Regina
AU  - Mericske-Stern R
LA  - eng
PT  - Journal Article
DEP - 20110323
PL  - United States
TA  - Clin Implant Dent Relat Res
JT  - Clinical implant dentistry and related research
JID - 100888977
RN  - 0 (Dental Implants)
RN  - 0 (Serum Albumin)
RN  - 0 (Tenascin)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - *Dental Implants/adverse effects
MH  - Gingival Crevicular Fluid/*chemistry/enzymology
MH  - Humans
MH  - Matrix Metalloproteinase 9/analysis/*metabolism
MH  - Middle Aged
MH  - Peri-Implantitis/etiology/*metabolism
MH  - Regression Analysis
MH  - Serum Albumin/metabolism
MH  - Statistics, Nonparametric
MH  - Tenascin/analysis/*metabolism
EDAT- 2011/03/25 06:00
MHDA- 2013/11/05 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
AID - 10.1111/j.1708-8208.2010.00319.x [doi]
PST - ppublish
SO  - Clin Implant Dent Relat Res. 2012 Oct;14(5):672-81. doi: 
      10.1111/j.1708-8208.2010.00319.x. Epub 2011 Mar 23.