PMID- 21429236
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2042-4280 (Electronic)
IS  - 2042-4280 (Linking)
VI  - 1
IP  - 1
DP  - 2010 Dec 7
TI  - Chromosomal integration of an avian oncogenic herpesvirus reveals telomeric 
      preferences and evidence for lymphoma clonality.
PG  - 5
LID - 10.1186/2042-4280-1-5 [doi]
AB  - BACKGROUND: Herpesviruses are a major health concern for numerous organisms, 
      including humans, causing both acute and chronic infections recurrent over an 
      individual's lifespan. Marek's disease virus (MDV) is a highly contagious 
      herpesvirus which causes a neoplastic condition in chicken populations. Several 
      vertebrate-infecting herpesviruses have been shown to exist in an integrated 
      state during latent periods of infection. However the status of MDV during 
      latency has been a topic of debate. RESULTS: Here we employed high-resolution 
      multi-color fluorescence in situ hybridization (FISH) to show integration of MDV 
      at the telomeres of chicken chromosomes. Cytogenomic mapping of the chromosomal 
      integrations allowed us to examine the clonal relationships among lymphomas 
      within individuals, whereas analysis of tumors from multiple individuals 
      indicated the potential for chromosomal preferences. CONCLUSIONS: Our data 
      highlight that substantive genome-level interactions between the virus and host 
      exist, and merit consideration for their potential impact and role in key aspects 
      of herpesvirus pathobiology including infection, latency, cellular 
      transformation, latency-breaks and viral evolution.
FAU - Robinson, Charmaine M
AU  - Robinson CM
AD  - Department of Animal Science, University of California, Davis, CA 95616, USA. 
      medelany@ucdavis.edu.
FAU - Hunt, Henry D
AU  - Hunt HD
FAU - Cheng, Hans H
AU  - Cheng HH
FAU - Delany, Mary E
AU  - Delany ME
LA  - eng
PT  - Journal Article
DEP - 20101207
PL  - England
TA  - Herpesviridae
JT  - Herpesviridae
JID - 101551529
PMC - PMC3063227
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
PMCR- 2010/12/07
CRDT- 2011/03/25 06:00
PHST- 2010/09/20 00:00 [received]
PHST- 2010/12/07 00:00 [accepted]
PHST- 2011/03/25 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PHST- 2010/12/07 00:00 [pmc-release]
AID - 2042-4280-1-5 [pii]
AID - 10.1186/2042-4280-1-5 [doi]
PST - epublish
SO  - Herpesviridae. 2010 Dec 7;1(1):5. doi: 10.1186/2042-4280-1-5.