PMID- 21429379
OWN - NLM
STAT- MEDLINE
DCOM- 20120402
LR  - 20110324
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 32
IP  - 2
DP  - 2011 Feb
TI  - [Clinical study of heparin-induced thrombocytopenia].
PG  - 115-7
AB  - OBJECTIVE: To observe the incidence of heparin-induced thrombocytopenia (HIT) in 
      patients received unfractionated heparin (UFH) treatment, and explore the 
      feasibility of monitoring HIT by platelet counts, as well as the significance of 
      HIT-antibody test in HIT diagnosis. METHODS: 145 patients received UFH treatment 
      in Vascular Surgery Department were studied. Before and after the UFH treatment, 
      platelet counts, HIT-antibody ELISA test and heparin-induced platelet aggregation 
      (HIPA) were tested. RESULTS: Among the 145 patients, thrombocytopenia occurred in 
      40 (27.6%) cases, HIT-antibody ELISA test positive in 59 (40.7%) cases, HIPA test 
      positive in 26 (17.9%) cases. The HIT was diagnosed in 24 (16.5%) cases, and 
      heparin-induced thrombocytopenia and thrombosis (HITTS) occurred in 5 (3.4% in 
      all cases, and 20.8% in HIT patients). In HIT patients, 15 patients (62.5%) were 
      thrombocytopenia, HIT-antibody positive and HIPA test positive. Platelet counts 
      in all of the 24 patients recovered to normal or level before UFH treatment in 
      3-6 days after heparin withdrawal therapy. CONCLUSION: HIT can be early diagnosed 
      by monitoring platelet counts, HIT-antibody ELISA test and HIPA test. Withdrawal 
      of heparin therapy in time and use of alternative anticoagulant, HITTS rate might 
      be expected to decline further.
FAU - Wang, Jing-hua
AU  - Wang JH
AD  - Department of Hematology, the Second Affiliated Hospital, Harbin Medical 
      University, Harbin 150086, China.
FAU - Wang, Chun-ying
AU  - Wang CY
FAU - Xie, Rui
AU  - Xie R
FAU - Che, De-hai
AU  - Che DH
FAU - Jia, Rui-chun
AU  - Jia RC
FAU - Ju, Wei
AU  - Ju W
FAU - Miao, Mei-juan
AU  - Miao MJ
FAU - Wang, Hui
AU  - Wang H
FAU - Jiang, Yan
AU  - Jiang Y
FAU - Tong, Dong-xia
AU  - Tong DX
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anticoagulants/*adverse effects
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Heparin/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Platelet Aggregation
MH  - Platelet Count
MH  - Thrombocytopenia/*chemically induced/*diagnosis
EDAT- 2011/03/25 06:00
MHDA- 2012/04/03 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2012/04/03 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2011 Feb;32(2):115-7.