PMID- 21429395
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20110324
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 32
IP  - 1
DP  - 2011 Jan
TI  - [Report of ten cases of hematologic malignancies with idic(20q-) and literature 
      review].
PG  - 17-20
AB  - OBJECTIVE: To analyze the clinical and molecular cytogenetic features of 
      hematologic malignancies with idic(20q-). METHODS: The clinical data of 10 
      patients with idic (20q-) were analyzed. Karyotyping analysis was carried out 
      with R banding technique. A CEP20 probe was used to perform single-color 
      fluorescence in situ hybridization (FISH). A subtelomeric probe for 20q and a 
      locus-specific probe for 20q12 were used to perform dual-color FISH. The 
      literatures of hematologic malignancies with idic(20q-) were reviewed. RESULTS: 
      Of the 10 cases, 2 were diagnosed as acute erythroid leukemia, 1 primary 
      myelofibrosis, 3 myelodysplastic syndromes (MDS) and 4 highly suspected (HS-MDS). 
      Karyotype analysis showed that one of the normal chromosome 20 allele was 
      substituted by one or two metacentric isochromosomes smaller than the normal one 
      in all 10 cases. It was confirmed to be der(20)del(20)(q11q13)idic(20)(p11), 
      i.e., idic(20q-) by FISH assay. Partial cells in 2 of the 10 cases had 20q- as 
      the sole karyotypic anomaly. CONCLUSION: Idic(20q-) results from a pre-existing 
      del(20q) and is strongly associated with MDS and acute erythroid leukemia. 
      Idic(20q-) as a recurrent cytogenetic abnormality is helpful for diagnosing 
      HS-MDS in patients with cytopenia but only slight or absent dysplasia.
FAU - Han, Yong-sheng
AU  - Han YS
AD  - Jiangsu Institute of Hematology, Thrombosis and Hemostasis, Suzhou 215006, China.
FAU - Xue, Yong-quan
AU  - Xue YQ
FAU - Li, Tian-yu
AU  - Li TY
FAU - Zhang, Jun
AU  - Zhang J
FAU - Chen, Su-ning
AU  - Chen SN
FAU - Pan, Jin-lan
AU  - Pan JL
FAU - Wu, Ya-fang
AU  - Wu YF
FAU - Wang, Yong
AU  - Wang Y
FAU - Shen, Juan
AU  - Shen J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Chromosome Aberrations
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 20/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Isochromosomes
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/diagnosis/*genetics
EDAT- 2011/03/25 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2011 Jan;32(1):17-20.