PMID- 21429451
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20111117
IS  - 2090-2387 (Electronic)
IS  - 1687-1979 (Linking)
VI  - 12
IP  - 1
DP  - 2011 Mar
TI  - The association of HLA class II DR B1 alleles with HCV infection in Egyptian 
      children.
PG  - 25-8
LID - 10.1016/j.ajg.2011.01.007 [doi]
AB  - BACKGROUND AND STUDY AIMS: Human leucocyte antigens (HLA) class II appear to play 
      an important role in the individual's immune response to viral infection. The aim 
      of this study is to assess the relationship between HLA class II antigens with 
      the clinical, laboratory and histopathological state of the liver in Egyptian 
      children and adolescents with chronic hepatitis C virus (HCV) infection. PATIENTS 
      AND METHODS: The study included 46 chronically infected HCV children and 
      adolescents without - hepatitis B virus (HBV) nor human immunodeficiency virus - 
      (HIV). Their mean age was 10.4+/-4.23years (3-17). HLA-DRB typing was done by 
      polymerase chain reaction (PCR) for the patients and 20 control subjects. 
      Biochemical and haematological parameters were assessed as well as a liver biopsy 
      was taken from the included patients. RESULTS: The most frequent alleles 
      demonstrated among patients were DRB1 *03, DRB1 *04 and DRB1 *13 (45.6%, 39.1% and 
      26.1%), respectively. Analysis of DRB1 frequencies between patients and control 
      revealed that DRB1*15 is significantly reduced among patients when compared with 
      the control group (p<0.01). Patients possessing the allele DRB1*03 had 
      significantly reduced platelet count (p=0.03), and this allele was presented to a 
      greater extent in patients with minimal grade of inflammation. Patients with 
      DRB1*04 had significantly low serum albumin (p=0.04) and patients with DRB1*13 
      had significantly high serum aspartate aminotransferase (AST) levels (p=0.05). 
      CONCLUSION: In Egyptian HCV-infected children, special HLA patterns were found; 
      HLA DRB1*03 was present in nearly half of the patients, while the frequency of 
      HLA DRB1*15 was significantly reduced among the cases in comparison to the 
      control subjects.
CI  - Copyright (c) 2011 Arab Journal of Gastroenterology. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Yosry, Ayman
AU  - Yosry A
AD  - Department of Tropical Medicine, Cairo University, Cairo, Egypt.
FAU - Fouad, Rabab
AU  - Fouad R
FAU - Mahmoud, Sherine
AU  - Mahmoud S
FAU - El-Raziky, Mona S
AU  - El-Raziky MS
FAU - El-Hennawy, Ahmed
AU  - El-Hennawy A
FAU - Ghoneim, Mona A
AU  - Ghoneim MA
LA  - eng
PT  - Journal Article
DEP - 20110218
PL  - Egypt
TA  - Arab J Gastroenterol
JT  - Arab journal of gastroenterology : the official publication of the Pan-Arab 
      Association of Gastroenterology
JID - 101298363
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Serum Albumin)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
SB  - IM
MH  - Adolescent
MH  - Aspartate Aminotransferases/blood
MH  - Biopsy
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Egypt
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Hepatitis C, Chronic/blood/*genetics/pathology/physiopathology
MH  - Humans
MH  - Liver/pathology
MH  - Male
MH  - Platelet Count
MH  - Polymerase Chain Reaction
MH  - Serum Albumin/analysis
EDAT- 2011/03/25 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/25 06:00
PHST- 2010/05/21 00:00 [received]
PHST- 2010/11/15 00:00 [revised]
PHST- 2011/01/07 00:00 [accepted]
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - S1687-1979(11)00010-4 [pii]
AID - 10.1016/j.ajg.2011.01.007 [doi]
PST - ppublish
SO  - Arab J Gastroenterol. 2011 Mar;12(1):25-8. doi: 10.1016/j.ajg.2011.01.007. Epub 
      2011 Feb 18.