PMID- 21430090
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20151119
IS  - 1479-9731 (Electronic)
IS  - 1479-9723 (Linking)
VI  - 8
IP  - 2
DP  - 2011
TI  - Fatigue in COPD: prevalence and effect on outcomes in pulmonary rehabilitation.
PG  - 119-28
LID - 10.1177/1479972310396737 [doi]
AB  - Patients with chronic obstructive pulmonary disease (COPD) complain of dyspnea 
      and fatigue. We sought to estimate the prevalence of high fatigue in this 
      population and to determine whether individuals with high fatigue had a different 
      response to pulmonary rehabilitation. This observational study was embedded 
      within a randomized trial. Participants underwent 3 months of pulmonary 
      rehabilitation including education and exercise training. We divided 251 
      individuals into low and high fatigue groups using population normal scores of 
      the SF-36 vitality domain. Baseline data included spirometry, 6-minute walk 
      distance (6MWD), peak exercise capacity, constant workrate cycling endurance 
      time, and questionnaires including the St. George's and Chronic Respiratory 
      questionnaires (SGRQ, CRQ). The response to pulmonary rehabilitation was 
      evaluated using changes in these measures at 3 months and 1 year after entry. 
      High fatigue was present in 97/251 (39%) of patients. High fatigue patients were 
      younger, had more depressive symptoms, greater dyspnea and poorer SGRQ scores (p 
      < 0.01). They also had lower 6MWD, endurance times, and peak volume of oxygen 
      consumption (VO(2); p < 0.05). Patients in both groups improved similarly in 
      their dyspnea, the 6MWD and endurance time. High-fatigue patients had greater 
      improvements in both the CRQ fatigue (by 0.74 more points) and the SGRQ scores 
      (by 6.0 points; p < 0.01), with clinically significant gains maintained at 1 
      year. This study suggests that high levels of fatigue is a common feature in 
      patients with COPD. They have a lower exercise capacity and a lower health 
      status. However, they benefit from pulmonary rehabilitation.
FAU - Baltzan, Marcel A
AU  - Baltzan MA
AD  - Mount Sinai Hospital Center, Montreal, Canada. marc.baltzan@clinepi.mcgill.ca
FAU - Scott, Adrienne S
AU  - Scott AS
FAU - Wolkove, Norman
AU  - Wolkove N
FAU - Bailes, Sally
AU  - Bailes S
FAU - Bernard, Sarah
AU  - Bernard S
FAU - Bourbeau, Jean
AU  - Bourbeau J
FAU - Maltais, Francois
AU  - Maltais F
CN  - Canadian COPD Pulmonary Rehabilitation Research Group
LA  - eng
GR  - MCT-63162/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110323
PL  - England
TA  - Chron Respir Dis
JT  - Chronic respiratory disease
JID - 101197408
SB  - IM
MH  - Aged
MH  - Dyspnea/etiology/physiopathology
MH  - Exercise/physiology
MH  - Exercise Test
MH  - Exercise Tolerance/physiology
MH  - Fatigue/*epidemiology/*etiology
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/physiology
MH  - Patient Education as Topic
MH  - Prevalence
MH  - Pulmonary Disease, Chronic 
      Obstructive/*complications/physiopathology/*rehabilitation
MH  - Quality of Life
MH  - Surveys and Questionnaires
EDAT- 2011/03/25 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - 1479972310396737 [pii]
AID - 10.1177/1479972310396737 [doi]
PST - ppublish
SO  - Chron Respir Dis. 2011;8(2):119-28. doi: 10.1177/1479972310396737. Epub 2011 Mar 
      23.