PMID- 21430113
OWN - NLM
STAT- MEDLINE
DCOM- 20110728
LR  - 20240315
IS  - 1938-3207 (Electronic)
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 93
IP  - 6
DP  - 2011 Jun
TI  - Predicting cardiovascular disease risk factors in midadulthood from childhood 
      body mass index: utility of different cutoffs for childhood body mass index.
PG  - 1204-11
LID - 10.3945/ajcn.110.001222 [doi]
AB  - BACKGROUND: Identifying adults at increased risk of cardiovascular disease (CVD) 
      on the basis of childhood body mass index (BMI) could be informative for disease 
      prevention but depends on the utility of childhood BMI cutoffs. OBJECTIVE: We 
      aimed to establish how well the International Obesity Task Force (IOTF) and 
      population-specific cutoffs for childhood BMI predict CVD risk factors in 
      midadulthood. DESIGN: We used the 1958 British birth cohort, whose BMI measures 
      were collected at 7, 11, and 16 y and whose CVD risk factors (obesity, 
      hypertension, adverse lipid concentrations, and type 2 diabetes risk) were 
      collected at 45 y. The sensitivity and specificity of IOTF and 
      population-specific cutoffs for childhood BMI were calculated for each CVD risk 
      factor. RESULTS: The prevalence of overweight or obesity was low in childhood 
      (<11%, IOTF cutoffs) compared with that in adulthood (75% men, 56% women). The 
      IOTF cutoffs had high specificities (91.6-97.9%) but low sensitivities 
      (7.1-31.5%) for predicting adult outcomes. In comparison, population-specific 
      cutoffs identified large groups of children (eg, >38% for predicting adult 
      obesity) who had improved sensitivities (17.3-67.3%) but lower specificities 
      (52.9-84.6%) compared with IOTF cutoffs. Accelerated BMI gains in childhood 
      predicted adult obesity and type 2 diabetes risk, but prediction was no greater 
      than that for childhood BMI at one age (area under the curve: 0.55-0.65 compared 
      with 0.59-0.75). Childhood BMI and BMI gain were weak predictors of adult 
      hypertension and adverse lipid concentrations. CONCLUSION: Neither the IOTF 
      cutoffs nor our population-specific cutoffs for childhood BMI are adequate 
      diagnostic tools for adult CVD risk factors in a population experiencing rapid 
      changes in obesity prevalence over their lifetime.
FAU - Li, Leah
AU  - Li L
AD  - MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, 
      London, United Kingdom. l.li@ich.ucl.ac.uk
FAU - Pinot de Moira, Angela
AU  - Pinot de Moira A
FAU - Power, Chris
AU  - Power C
LA  - eng
GR  - G0000934/MRC_/Medical Research Council/United Kingdom
GR  - G0400546/MRC_/Medical Research Council/United Kingdom
GR  - G0601941/MRC_/Medical Research Council/United Kingdom
GR  - G0601941(81835)/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110323
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
SB  - IM
MH  - Adolescent
MH  - Area Under Curve
MH  - *Body Mass Index
MH  - Cardiovascular Diseases/epidemiology/*etiology
MH  - Child
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/etiology
MH  - Female
MH  - Guidelines as Topic
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*complications/diagnosis/epidemiology
MH  - Prognosis
MH  - Reference Values
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - United Kingdom/epidemiology
MH  - *Weight Gain
PMC - PMC3308204
MID - UKMS47217
OID - NLM: UKMS47217
EDAT- 2011/03/25 06:00
MHDA- 2011/07/29 06:00
PMCR- 2012/03/20
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/07/29 06:00 [medline]
PHST- 2012/03/20 00:00 [pmc-release]
AID - S0002-9165(23)12950-9 [pii]
AID - 10.3945/ajcn.110.001222 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2011 Jun;93(6):1204-11. doi: 10.3945/ajcn.110.001222. Epub 2011 
      Mar 23.