PMID- 21432193
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211020
IS  - 1342-078X (Print)
IS  - 1347-4715 (Electronic)
IS  - 1342-078X (Linking)
VI  - 5
IP  - 3
DP  - 2000 Oct
TI  - The use of docosahexaenoic acid supplementation to ameliorate the hyperactivity 
      of rat pups induced by in utero ethanol exposure.
PG  - 103-10
LID - 10.1265/ehpm.2000.103 [doi]
AB  - It has been demonstrated thatin utero ethanol (EtOH) exposure induces hyperactive 
      behavior and learning disturbances in offspring. In order to investigate the 
      effects of docosahexaenoic acid (DHA) on these neurobehavioral dysfunctions of 
      rat pups induced byin utero EtOH exposure, pregnant Wistar rats were divided into 
      four treatment groups depending on the type of oil added to the diet and drinking 
      water as follows; (a) 5% safflower oil with tap water (TW/n-6), (b) 3% safflower 
      oil and 2% DHA with tap water (TW/n-3), (c) 5% safflower oil with 10%-EtOH 
      (ET/n-6), (d) 3% safflower oil and 2% DHA with 10%-EtOH (ET/n-3) at gestational 
      day (GD) 7.10%-EtOH was administered to dams in ET/n-6 and ET/n-3 groups from GD 
      7 to the pups' weaning (postnatal week 4), and all pups were fed with the same 
      diet that was given to their dams during the entire examination period. The 
      open-field test and the water E-maze test were conducted for all pups, and a 
      spontaneous motor activity test and the Sidman electric shock avoidance test were 
      performed for some of male pups. Amounts of monoamine metabolites in striatum 
      were then determined, and fatty acid analyses of total brain lipids were 
      performed.The male pups in the ET/n-6 group showed significandy more rearing and 
      square-crossing movements in the open-field test, and significandy higher 
      spontaneous motor activity during the dark period in the daily cycle compared to 
      the males in the TW/n-6 group. The male pups in the ET/n-3 group showed fewer of 
      these behaviors in the open-field test compared to the ET/n-6 group males, and a 
      normal pattern of spontaneous motor activity.Learning disturbance induced byin 
      utero EtOH exposure was not observed in the E-shaped water maze, but was observed 
      in the avoidance rates in the Sidman electric shock avoidance test. However, 
      there was no significant modifying effect of DHA on the avoidance rates in EtOH 
      exposed pups.The analysis of the fatty acid composition of total lipids in the 
      brains of the pups revealed high levels of DHA in the diet reflected an increased 
      level of brain DHA and caused a decreased level of the brain arachidonic acid. 
      Retroco nversion from DHA to eicosapentaenoic acid was also observed. However, 
      there was no significant effect of DHA on the levels of monoamine 
      metabolites.These results support the hypothesis that DHA can counteract the 
      attention deficit hyperactivity disorder.
FAU - Furuya, H
AU  - Furuya H
AD  - Department of Community Health, Division of Community and Environmental Health, 
      Tokai University School of Medicine, 259-1193, Bohseidai Isehara, Kanagawa, 
      Japan.
FAU - Aikawa, H
AU  - Aikawa H
FAU - Yoshida, T
AU  - Yoshida T
FAU - Okazaki, I
AU  - Okazaki I
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Environ Health Prev Med
JT  - Environmental health and preventive medicine
JID - 9609642
PMC - PMC2723580
OTO - NOTNLM
OT  - docosahexaenoic acid
OT  - fetal alcohol effect
OT  - hyperactive behavior
OT  - learning behavior
OT  - monoamine metabolites
EDAT- 2000/10/01 00:00
MHDA- 2000/10/01 00:01
PMCR- 2001/10/01
CRDT- 2011/03/25 06:00
PHST- 1999/12/27 00:00 [received]
PHST- 2000/05/31 00:00 [accepted]
PHST- 2011/03/25 06:00 [entrez]
PHST- 2000/10/01 00:00 [pubmed]
PHST- 2000/10/01 00:01 [medline]
PHST- 2001/10/01 00:00 [pmc-release]
AID - 53103 [pii]
AID - 10.1265/ehpm.2000.103 [doi]
PST - ppublish
SO  - Environ Health Prev Med. 2000 Oct;5(3):103-10. doi: 10.1265/ehpm.2000.103.